RODENT IMAGING AND SPECTROSCOPY FACILITY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 2007年将安装两台新的最先进的磁共振仪器。其目标是为广泛的用户提供7T和9.4T的成像和光谱。高场强的啮齿动物研究具有多方面的优势，包括提高了灵敏度，改善了敏感性依赖的测量，如从细胞内脂肪到细胞外脂肪的分辨率，更广泛的化学位移分散，更简单的J偶联模式，以及更长的T1，这将有利于化学交换依赖现象。7T将是一款专门用于1H成像的16厘米RT钻孔仪器；将不提供x核。9.4T将是一台21厘米的RT钻孔仪器，致力于超高场成像和光谱研究，包括13C、31P、23Na等，以及最佳糖原成像。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Two new state-of-the-art MR instruments will be installed in 2007. The objective is to provide imaging and spectroscopy at 7T and 9.4T for a wide range of users. The high fields for rodent studies have multiple advantages, including improved sensitivity, improved susceptibility - dependent measurements such as resolution of intra- from extra-myocellular fat, wider chemical shift dispersion, simpler J coupling patterns, and longer T1s that will benefit chemical exchange-dependent phenomena. The 7T will be a 16 cm RT bore instrument dedicated exclusively to 1H imaging; x nucleus will not be available. The 9.4T will be a 21 cm RT bore instrument devoted to research in ultra-high field imaging and spectroscopy including 13C, 31P, 23Na, etc., as well as optimal glycogen imaging.