MONTE CARLO MODELLING OF TRI-MODAL SPECTROSCOPY SPECTRA FOR DETECTION OF EARLY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 激光生物医学研究中心的三模光谱(TMS)项目(NIH P41研究资源)结合了光散射、漫反射和本征荧光光谱来检测癌前病变(上皮异型增生)。正在对活体和体外组织标本进行人体受试者研究。迫切需要开发基于辐射输运的蒙特卡罗模拟来模拟光谱信号。这些结果将为改进TMS分析提供信息，并提供有关形态和生化组织成分在光学信号中的表现方式的洞察力。我们已经开发了蒙特卡罗程序，并将其用于初步研究。然而，由于数值模拟是耗时的，因此需要一台大型并行处理计算机。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The tri-modal spectroscopy (TMS) project of the Laser Biomedical Research Center (an NIH P41 Research Resource) employs the combination of light scattering, diffuse reflectance and intrinsic fluorescence spectroscopy to detect pre-cancer (epithelial dysplasia). Studies are being conducted on human subjects in vivo and on ex vivo tissue specimens. There is a pressing need to develop Monte Carlo simulations based on radiative transport to model the spectral signals. The results will provide information to improve TMS analysis and provide insight as to the way the morphological and biochemical tissue components manifest themselves in the optical signals. We have developed a Monte Carlo code and are using it in preliminary studies. However, because the numerical simulations are time consuming, a large parallel processing computer is required.