INVESTIGATION OF DWI TO EVALUATE PROSTATE THERMAL AND CRYO LESIONS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 引言：热消融和冷冻消融是前列腺癌微创治疗的有前途的方法。MRI能够引导治疗施源器的位置，在治疗期间测量组织温度，并在治疗后评价组织。对比增强成像和弥散加权成像都显示了热损伤，但DWI的优势是可重复性，因为它不需要注射造影剂。这项工作的目标是评估DWI作为一种方法，以估计组织活力后立即治疗。 方法：所有动物实验均由实验动物管理小组批准。对6例犬前列腺进行磁共振弥散加权成像，其中3例采用高强度超声热疗，3例采用冷冻消融。所有MR成像均在0.5 T Signa SP开放式MRI系统（GE，密尔沃基，WI）上采集。体线圈用作发射器。由前表面线圈和直肠内线圈组成的2通道相控阵线圈用作接收器。治疗前和前列腺恢复体温后行行线扫描弥散加权成像（LSDI）（TE/TR = 70/150 ms，矩阵= 256，带宽= 7.91 kHz，层厚= 5 mm，B = 10，360 s/mm 2）。计算扩散迹线数据并与氯化三苯基四唑（TTC）染色结果进行比较。在坏死和存活组织中测量表观扩散系数（ADC）值。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Thermal ablation and cryoablation are promising methods for the minimally treatment of prostate cancer. MRI provides the ability to guide the position of treatment applicator, to measure the tissue temperature during treatment, and to evaluate the tissue after the treatment. Contrast-enhanced imaging and diffusion-weighted imaging both demonstrate the thermal lesion, but the advantage to DWI is repeatability since it does not require an injection of contrast agent. The goal of this work is to evaluate DWI as a method to estimate tissue viability immediately after the treatment. Methods: All animal experiments were approved by the Administrative Panel on Laboratory Animal Care. Diffusion weighted imaging was performed in six canine prostates with MRI-guided high intensity ultrasound thermal therapy (3 cases) or cryoablation (3 cases). All MR imaging were acquired on the 0.5T Signa SP open MRI system (GE, Milwaukee, WI). The body coil was used as the transmitter. A 2-channel phase array coil consisting of an anterior surface coil and an endorectal coil was used as the receiver. Line scan diffusion weighted images (LSDI) (TE/TR = 70/150 ms, matrix = 256¿63, field of view = 24¿6 cm, LSDI inclination angle = 70¿, band width = 7.91 kHz, slice thickness = 5 mm, b = 10, 360 seconds/mm2) were acquired before the therapy and after the prostates returned to body temperature. Diffusion trace data were calculated and compared to the triphenyl tetrazolium chloride (TTC) staining result. The apparent diffusion coefficient (ADC) values were measured in both the necrotic and viable tissues.