CORE--MOLECULAR BIOLOGY

细胞和分子神经科学与神经遗传学 让·德·韦利斯和安东尼·坎帕诺尼，小组协调员 在过去的十年里，由Jean de Vellis和Anthony领导的研究小组 坎帕诺尼越来越多地采取类似的方法来调查潜在的 指导神经系统正常发育的机制以及 导致发育功能障碍的发病机制，即智力低下和发育 残疾(MRDD)。他们利用遗传学、分子生物学、细胞和分子生物学 神经科学将分析人类基因工程动物模型的机制 发育障碍。这个群体中的大多数MRRC研究人员都是 对神经系统的发育感兴趣。提出的另一个原因 坎帕诺尼和德韦利斯的组合是，他们将搬到三楼的 神经科学研究/MRRC大楼初春。他们建立了共享治理，以 利用大型共享实验室、程序室、间隔室和大型线性设备间。 因此，他们希望在他们的努力中产生更多的合作，以阐明 发育障碍的神经生物学和遗传学。一些遗传学家已经 位于附近的人类遗传学系。其中一个共同的研究兴趣是 干细胞的研究，这是一个与加州最近的倡议相关的领域，有望 补充资金。萌芽中的神经干细胞中心主任哈雷·科恩布卢姆 被聘为MRRC核心教员，精神病学和生物行为科学将 成为他的主要部门。Kornblum加入了Sun、Fan、Waschek、De Vellis和Cederbaum 他们对干细胞在发育和MRDD中的作用非常感兴趣。这项研究 这两个小组的进展按调查人员的字母顺序列出。

CELLULAR AND MOLECULAR NEUROSCIENCE AND NEUROGENETICS Jean de Vellis and Anthony Campagnoni, Group Coordinators During the last decade, the research groups headed by Jean de Vellis and Anthony Campagnoni have increasingly taken similar approaches to investigate the underlying mechanisms directing the normal development of the nervous system as well as the pathogenesis causing developmental dysfunctions, i.e. mental retardation and developmental disabilities (MRDD). They use genetics, molecular biology, and cellular and molecular neuroscience to analyze mechanisms in genetically-engineered animal models of human developmental disorders. The majority of MRRC researchers throughout this group are interested in the development of the nervous system. Another reason to present the Campagnoni and de Vellis groups together is that they will move to the third floor of the Neuroscience Research/MRRC Building in early spring. They have set up shared governance to utilize large shared laboratories, procedure rooms, vivarium, and a large linear equipment room. Therefore they expect to generate more collaborations in their efforts to elucidate the neurobiology and genetics of developmental disorders. Some of the geneticists are already located in the nearby Department of Human Genetics. One of the common research interests is the study of stem cells, an area relevant to the recent California initiative that will hopefully supplement funding. Harley Kornblum, the director of the budding Neural Stem Cell Center has been recruited as an MRRC core faculty and Psychiatry and Biobehavioral Sciences will become his primary department. Kornblum joins Sun, Fan, Waschek, de Vellis and Cederbaum who have major interest in stem cells for their role in development and MRDD. The research progress for these two groups is listed alphabetically by investigator.