Neuroscience Integration & Support

神经科学整合与支持核心 修订后的提案简介 正如前面在申请中指出的，我们2002年的提案有两个服务核心，支持基本服务 神经生物学课程。四个令人担忧的领域似乎贯穿了对这两个核心的审查， 这些担忧导致两家公司的评级都很一般(核心B：212，核心C：200)。令人担忧的是： (A)核心单位需要在概念上和方案上有更大的区别。 (B)一些核心组成部分被认为比其他组成部分强得多； (C)某些后勤方面需要进一步解释； (D)某些工作人员资格要求更多的文件。 作为回应，我们重新思考了提出两个神经生物学核心的理由。最终，我们 结论是，如果将两者结合起来，我们可以提出一个更好的建议：我们删除了组件 它们被认为不那么有说服力，增加了可以增强核心能力的组件，以及 制定了更全面的综合核心概念。正如修订后的提案将阐明的那样，我们 提供一个概念性的集成服务菜单，代表从基因/蛋白质的进展 对较大神经系统的神经生物学结构和功能的研究的发现。 尽管在上一个申请中提出的核心组件与 这一次，我们认为目前的提案是一个大大改进的，更好地表达，更 成熟的提案--几乎是一个新的提案。它当然代表了一个新的核心概念。因为 变化如此之大，我们认为指示保留的文本段落会更多 对于我们的评论家来说，这令人困惑，而不是有帮助。下面总结了已经发生的主要变化 这是为了加强我们的解除武装、复员和重返社会方案。

NEUROSCIENCE INTEGRATION & SUPPORT CORE Introduction to the Revised Proposal As noted earlier in the application, our 2002 proposal had two service cores supporting basic neurobiology programs. Four areas of concern appeared to cut across the review of these two cores, and these concerns led to mediocre ratings for both (Core B: 212, Core C: 200). The concerns were: (a) The cores units required greater differentiation conceptually and programmatically. (b) Some core components were judged substantially stronger than others; (c) Certain logistical aspects required further explanation; (d) Certain staff qualifications required more documentation. In response, we rethought the rationale for proposing two neurobiology cores. Ultimately, we concluded that we could make a stronger proposal if the two were combined: We removed components that were judged less compelling, added components that would enhance the core capabilities, and developed a more comprehensive integrative core concept. As the revised proposal will articulate, we offer a conceptually integrated menu of services that represent a progression from gene/protein discovery to the study of the neurobiological structure and function of larger neural systems. Although there is overlap between core components that were proposed in the last application and in this one, we believe that the present proposal is a vastly improved, much better articulated, more mature proposal - virtually a new proposal. It certainly represents a new core concept. Because the changes are so extensive, we thought that indicating text passages that were retained would be more confusing than helpful for our reviewers. What follows summarizes the major changes that have been made to strengthen our MRDDRC proposal.