Integrative Health Sciences

A2.目的、理由和目标 综合健康科学设施核心（IHSFC）的目的是促进和加强 基础研究发现转化为临床或公共卫生应用的速度， 约翰霍普金斯NIEHS城市环境健康中心的成员。合并的理由 并将我们现有的几个设施核心的功能增强到这个新结构中， 认识到解决城市环境卫生问题需要采取多学科办法 以及日益复杂的技术。我们过去的设施核心结构经常有意想不到的 “炉管”服务的后果。由于我们正致力协助处理跨部门的问题， 学科，我们设计了IHSFC，以简化中心研究人员的翻译能力， 通过创建一个“一站式”核心，包括服务，仪器和种子资金的研究 必须促进与公共卫生的联系。我们认为，IHSFC已经采取了我们所做的， 过去在几个设施的核心，并加强了这些服务在一个新的格式，将服务于该中心期间 下一个更新周期。 这一核心的具体目标是： 提供服务和获得仪器和技术，促进基础科学的整合 公共卫生研究，包括流行病学，预防和干预研究。 支持研究，以改善暴露特征，早期发现疾病风险，生物标志物 发现和发展与环境有关的疾病的预防干预措施。 加强研究人员和社区之间的伙伴关系，影响临床和 通过IHSFC与社区外展和教育核心的联系进行公共卫生研究 （COEC）在这个中心。 转化研究通常包括涉及人类的人群或基于临床的研究。 以减轻疾病负担为目标。无论这些研究是否涉及病因学或 积极干预，所有这些调查都必须经过公众广泛的人类主体审查 约翰霍普金斯彭博的卫生机构审查、提交和跟踪（PHIRST）委员会 公共卫生学院（http：//phirst.jhm.edu/）。所有教师都必须参加在线培训认证 关于人类受试者研究的伦理问题（见www.citiprogram.org）。此外，参与调查的 强烈鼓励临床试验利用临床试验中心（http：cct.jhsph.edu） 在学校提供伦理研究的指导，以及数据安全和监测的发展 板.因此，在这方面，广泛的机构承诺和基础设施对人类受试者的研究 学校消除了IHSFC重复这些活动的必要性。

A2. Purpose, Rationale and Objectives The purpose of the Integrated Health Sciences Facility Core (IHSFC) is to facilitate and enhance the speed at which translation of basic research discovery occurs into clinical or public health applications by members of the Johns Hopkins NIEHS Center in Urban Environmental Health. The rationale for incorporating and enhancing the functions of several of our existing facility cores into this new structure is built upon the recognition that addressing the problems of urban environmental health requires multidisciplinary approaches and ever increasing complex technologies. Our past facility core structure often had the unintended consequence of "stove piping" services. Since we are striving to facilitate the tackling of problems across disciplines, we have designed the IHSFC to streamline the ability of Center investigators to do translational research by creating a "one-stop" core that encompasses the services, instrumentation and seed-money necessary to promote linkages to public health. We feel that the IHSFC has taken what we have done well in the past in several facility cores and enhanced these services in a new format that will serve the Center during the next renewal cycle. The specific objectives of this core are: ¿ To provide services and access to instrumentation and technologies that foster integration of basic science into public health research, including epidemiology, prevention and intervention studies. ¿ To support research to improve exposure characterization, early detection of disease risk, biomarker discovery and development of preventive interventions for environmentally related diseases. ¿ To enhance partnerships between researchers and the community that impact on conduct of clinical and public health research through the linkage of the IHSFC with the Community Outreach and Education Core (COEC) in this Center. Translational research always encompasses population or clinical-based investigations that involve human subjects with the goal of reducing disease burden. Irrespective of whether these studies involve etiologic or active interventions, all of these investigations must undergo extensive human subjects review by the Public Health Institutional Review, Submission and Tracking (PHIRST) committee at the Johns Hopkins Bloomberg School of Public Health (http://phirst.jhsph.edu/). All faculty are required to take online training certification about the ethics of human subjects research (at www.citiprogram.org). Furthermore, investigators involved in clinical trials are strongly encouraged to avail themselves of the Center for Clinical Trials (http://cct.jhsph.edu) in the School to provide guidance for ethical research, and the development of data safety and monitoring boards. Thus, the extensive institutional commitment and infrastructure for human subject's research at this School obviates the need for the IHSFC to duplicate these activities.