THE BENEFICIAL METABOLIC EFFECTS OF INTERMITTENT FASTING

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 治疗性禁食的补充和替代医学实践被推荐作为肥胖和其他代谢疾病的治疗方法。 肥胖症是目前美国最严重的营养失调症，降低肥胖症的患病率是“健康人2010”的主要目标。 然而，尽管有这些目标，肥胖症的流行率仍在继续上升。 迫切需要新的肥胖症治疗选择。 传统热量限制的减肥和代谢益处往往是小的和短暂的。 有强有力的数据支持治疗性禁食减肥的各种益处和持久性。 然而，持续禁食是不切实际的，并且增加了相关的不良事件。 最近，动物数据表明，间歇性禁食（每隔一天）具有与长期禁食相似的代谢益处。 还有数据表明，间歇性禁食比长期禁食更安全，也比传统的热量限制更容易耐受。 本文所述的研究旨在检验总体假设，即治疗性间歇性禁食（IF）将是比适度每日热量限制（CR）更有效的肥胖治疗。将处理以下具体目标： 1)确定IF与CR相比对体重减轻和身体组成的影响 2)探索IF与CR相比对胰岛素敏感性、血脂水平和血压的影响 3)评价IF与CR相比的安全性和耐受性

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The both complementary and alternative medicine practice of therapeutic fasting is recommended as a treatment of obesity and other metabolic diseases. Obesity is currently the most significant nutritional disorder in the United States and a reduction in the prevalence of obesity is targeted as a major objective in "Healthy People 2010". However, despite these goals, the prevalence of obesity is continuing to rise. New treatment options for obesity are desparately needed. The weight loss and metabolic benefits of traditional caloric restriction tend to be small and short lived. There are strong data to support a variety of benefits and durability of weight loss with therapeutic fasting. However, persistent fasting is not practical and has increased associated adverse events. Recently, animal data suggests that intermittent fasting (every other day) has similar metabolic benefits to prolonged fasting. There are also data to suggest that intermittent fasting will be safer than prolonged fasting and easier to tolerate than traditional caloric restriction. The studies described herein are designed to test the overall hypothesis that therapeutic intermittent fasting (IF) will be a more effective treatment for obesity than moderate daily caloric restriction (CR). The following specific aims will be addressed: 1) To determine the effect of IF compared to CR on weight loss and body composition 2) To explore the effect of IF compared to CR on insulin sensitivity, lipid levels, and blood pressure 3) To evaluate the safety and tolerability of IF compared to CR