EFFECT OF PREGNANCY ON ANXIETY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项拟议的研究是一项先导性研究，旨在获得关于重新提交NIH拨款申请所需的招募和保留率、怀孕对焦虑的影响以及断奶对焦虑的影响的额外先导数据。 目的1：评价妊娠对50例帕金森病、强迫症和广泛性焦虑症患者焦虑症状病程和严重程度的影响。假设1)-在研究开始时患有亚阈值或全标准PD、OCD或GAD的受试者，怀孕期间强迫症和GAD症状会增加，PD症状会减少。 目的2：确定哺乳和断奶对自主神经唤醒和焦虑的调节程度。假设2a)--快速脱机将与自主神经唤醒的增加有关。自主神经的觉醒表现为呼吸性窦性心律不齐(迷走神经紧张性)和迷走神经刹车的减少，以及收缩压的升高。假设2b)--在基线水平上，快速脱机将与焦虑症妇女的焦虑症状恶化有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The proposed study is a pilot study, designed to obtain additional pilot data regarding recruitment and retention rates, effects of pregnancy on axiety, and effects of weaning on anxiety, needed for resubmission of an NIH grant application. Aim 1: To evaluate potential differential effects of pregnancy on the course and severity of anxiety symptoms in 50 women with PD, OCD or GAD. Hypothesis 1) - In subjects with subthreshold or full criteria PD, OCD, or GAD at study entry, OCD and GAD symptoms will increase during pregnancy and PD symtoms will decrease. Aim 2: To determine the extent to which lactation and weaning modulate autonomic arousal and anxiety. Hypothesis 2a) - Rapid weaning will be associated with an increase in autonomic arousal. Autonomic arousal will be represented by reductions in respiratory sinus arrhythmia (vagal tone) and vagal brake, and as an increase in systolic blood pressure. Hypothesis 2b) - Rapid weaning will be associated with worsening anxiety symptoms in women with anxiety disorders at baseline.