EFFECT OF ACETAMINOPHEN (TYLENOL) ON HUMAN LYMPHOCYTES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 作为国际药典药物性肝损伤研究计划的一部分，GCRC#2122、2228、2265方案被设计用来进一步定义人类药物性肝损伤的自然历史和机制。作为对这些临床研究的补充，调查小组一直在开发基于实验室的方案，以了解更多关于潜在损伤机制的信息。一个具体的例子是探索扑热息痛对淋巴细胞的影响。这项提议寻求允许招募一组30人，他们愿意在研究过程中反复献血，用于这些体外实验。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. As part of the PI's research program in drug-induced liver injury, protocols GCRC #2122, 2228, 2265 have been designed to further define the natural history and mechanisms os drug-induced liver injury in humans. As a complement to these clinical studies, the investigative team has been developing laboratory-based protocols to learn more about potential mechanisms of injury. A specific example is exploring the effect of acetaminophen on lymphocytes. This proposal seeks permission to enroll a cohort of 30 individuals who are willing to donate blood repeatedly over the course of the study to be used for these in vitro experiments.