CORE--DATA MANAGEMENT AND COMPUTING

数据管理和计算核心的目标是为本计划项目中使用的遗传型和表型数据提供数据库管理服务。该核心单位还负责数据质量控制，支持应用软件，为本计划项目使用的计算机提供网络和系统管理，并保护项目数据的机密性和安全性。这个核心单位在拟议的赠款期间的具体目标是：(1)管理本方案项目中使用的计算机化数据的获取和控制，并维护实验室数据采集软件；(2)维护在研究过程中收集的样本的库存；(3)管理实验室间的文件传输；(4)维护用于处理梯度凝胶数据的软件；(5)构建和维护 (6)评估收集的数据的质量；(7)管理和纠正不同的基因类型；(8)计算IBD矩阵；(9)将原始数据转换为适合进行基因分析的形式；(10)根据需要进一步开发和改进本计划项目中使用的软件；(11)按需要承担系统编程任务；(12)维护系统和数据备份程序；(13)监督系统和网络安全；以及(14)建立 用于传播有关此计划项目的信息的网站。

The objectives of the Data Management and Computing Core are to provide database management services for genotypic and phenotypic data used in this Program Project. This Core Unit also is responsible for data quality control, supports applications software, provides network and systems management for computers used by this Program Project, and protects the confidentiality and security of project data. Specific aims of this core unit during the proposed grant period are (1) to manage acquisition and control of computerized data used in this Program Project, and to maintain laboratory data acquisition software; (2) to maintain an inventory of samples collected in the course of the research; (3) to manage inter-laboratory file transfer; (4) to maintain the software used for processing gradient gel data; (5) to construct and maintain computerized pedigrees of family data; (6) to assess the quality of the data collected; (7) to manage and correct discrepant genotypes; (8) to calculate IBD matrices; (9) to transform raw data into forms suitable for genetic analysis; (10) to further develop and enhance software used in this Program Project as needed; (11) to undertake systems programming tasks as needed to maintain our computer system and its communications network; (12) to maintain system and data backup procedures; (13) to oversee system and network security; and (14) to establish a Web site for dissemination of information about this Program Project.