GENETIC BASIS OF ANDROGEN EXCESS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 多囊卵巢综合征(PCOS)是一种原因不明的慢性高雄激素血症的异质性综合征。它似乎是一种复杂的性状，既有遗传因素，也有非遗传因素。这项研究是为了验证这样一种假设，即17？-HSD5的激活变异有助于女性的高雄激素血症，并且特定的表型与这些变异有关。该项目将高雄激素性儿童和成人与阶段和体重匹配的健康对照组进行比较。结果测量包括卵巢和肾上腺功能测试、糖耐量测试和盆腔超声参数。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Polycystic ovary syndrome (PCOS) is a heterogeneous syndrome of unexplained chronic hyperandrogenism. It appears to arise as a complex trait with contributions from both heritable and non-heritable factors. This study is to test the hypothesis that activating variants of 17¿-HSD5 contribute to hyperandrogenism in women and that a specific phenotype is associated with these variants. This project compares hyperandrogenic children and adults with stage- and weight-matched healthy controls. Outcome measure include ovarian and adrenal function test, glucose tolerance test, and pelvic ultrasound parameters.