LH/FSH/INSULIN INTERACTIONS IN PCOS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们将测试一种假设，即激活17？HSD5基因变异(G-138)或其他潜在的17？HSD5激活变异的特定候选基因与细胞因素相互作用，影响正常和PCOS患者的卵巢睾酮分泌。研究连续3-4个月的吡格列酮和亮丙瑞林对卵泡刺激素(FSH)启动前后卵巢对人绒毛膜促性腺激素(HCG)刺激的影响。对健康的成年志愿者进行研究，以建立对hCG？FSH检测的正常反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We will test the hypothesis that a specific candidate activating 17¿-HSD5 gene variant (G-138), or other potential 17¿-HSD5 activating variants, interacts with the cellular factors to affect ovarian testosterone secretion in both normal and PCOS patients. The study includes study of the effect of successive 3-4 month courses of pioglitazone and depot leuprolide on the ovarian response to human chorionic gonadotropin (hCG) stimulation before and after follicle stimulating hormone (FSH) priming. Healthy adult volunteers are studied to establish normal responses to hCG ¿ FSH testing.