EFFECT OF DIETARY FAT ON SYMPATHETIC NERVE ACTIVITY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究将阐明交感神经激活进食的机制。已知胰岛素在碳水化合物摄入后会诱导交感神经系统激活，但在脂肪摄入后不会增加。因此，脂肪负荷后交感神经活动(SNA)的增加可能表明胰岛素以外的介质参与其中。这些研究人员建议研究瘦和肥胖受试者对口服脂肪、碳水化合物或水的急性肌肉和皮肤SNA反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will clarify the mechanisms of sympathoactivation to meal ingestion. Insulin is known to induce sympathetic nervous system activation after carbohydrate administration but is not increased after fat ingestion. Thus, increases in sympathetic nerve activity (SNA) after a fat load would suggest the involvement of mediators other than insulin. These investigators propose to study the acute muscle and skin SNA response to oral fat, carbohydrate or water in lean and obese subjects.