EXPERIMENTAL THERAPEUTICS IN CRITICAL ILLNESS

描述(由申请人提供)： 超出提供的空间。这项博士后培训计划建议旨在培训研究员，每名研究员为期2至3年，从事与心肺和肾脏应激反应相关的基础科学研究。学员的总体研究重点是基础科学研究的四个相互关联的层面：1)细胞和分子免疫生物学；2)器官损伤的细胞基础；3)器官-系统相互作用；以及4)以结果为基础的研究。这种方法强调了重症监护医学的基本基础，需要将细胞和分子生物学整合到器官系统监测中，并遵循治疗方法来确定其对社会相关结果的影响。这些研究领域与教职员工合作的校外研究补助金不谋而合。研究计划是很好的培训工具，因为它们提出了广泛的问题，可以就这些问题进行精确的、有针对性的个人研究培训工作。师资队伍反映了一批经验丰富、敬业的资深院士，均有校外科研培训支持和培训经验。在完成培训计划后，研究员将了解如何设计、执行和完成实验，以回答危重患者提出的特定问题。因此，这位研究员不仅将接受先进的实验室方法论方面的培训，还将接受应用未来实验问题所需的思维过程方面的培训，因为这些问题与危重患者的现实生活问题有关。所有受训人员将参加匹兹堡大学基础科学系提供的正式研究生课程。有些人可能会完成获得高级学位所必需的课程。大多数培训将在主要培训师的实验室进行，使用经过仔细考虑的师徒制度。这一培训技术结合了受训者和培训者之间的每周会议以及一小时的研究培训研讨会。此外，受训者的正式研究报告将每两年向当地研究界发表一次。

DESCRIPTION (provided by applicant): EXCEED THE SPACE PROVIDED. This postdoctoral training program proposal is designed to train fellows, for a period of 2 or 3 years each, in basic science research relevant to cardiopulmonary and renal responses to stress. The overall research focus of the trainees is on four inter-related levels of basic science investigation: 1) cell and molecular immunobiology; 2) cellular basis of organ injury; 3) organ-system interaction; and 4) outcomes-based research. This approach underscores the essential basis of critical care medicine, requiring an integration of cell and molecular biology to organ-system monitoring, and following therapies to define their effects on socially relevant outcomes. These areas of research coincide with extramural research grants on which the faculty collaborate. The research plans are excellent vehicles for training because they ask broad questions on which precise, well-targeted individual research training efforts can be staged. The faculty reflect an experienced and dedicated group of senior academicians, and all have extramural research training support and training experience. Upon completion of the training program, the fellow will understand how to design, execute, and complete experiments to answer specific questions derived from critically ill patients. Thus, the fellow will be trained not only in advanced laboratory methodology, but also in the thought processes needed to apply future experimental problems as they relate to real life problems in critically ill patients. All trainees will take formal postgraduate courses offered by the basic science departments of the University of Pittsburgh. Some may complete coursework necessary to receive advanced degrees. Most training will take place in the laboratories of the principal trainers using a carefully thought-out version of the master-apprentice system. This training technique combines weekly meetings between the trainee and trainer as well as a one hour research training seminar. Furthermore, formal research presentations by the trainees will be given biannually to the local research community.