Integrated Physiology Training: Molecule to Organism

描述（由申请人提供）：在过去的二十年中，全国各地的生理学部门的培训经历了一种转变，这种转变使学生无法从整个动物到细胞和分子水平的学科广度上进行透彻的理解。威斯康星医学院（MCW）的生理学系是一个例外，它提供研究培训，强调所有这些层面的知识的整合，并培养对这些知识与疾病过程之间关系的认识。根据目前的建议，我们将继续每年为6名NIH支持的受训者提供细胞、分子和全动物生理学方面的特殊培训。拟议的培训的一个独特方面是指导计划，其中包括来自各种传统领域的基础科学家以及临床科学家。研究生将在全国范围内招募，并根据本科学历、研究经验和对研究和培训事业的承诺进行选择。学生完成研究生院的第一年，他们将被考虑为NIH培训支持。学员的选择将主要基于在研究生院第一年的课程作业和研究实验室的表现。学员为MCW生物医学研究生院全日制博士研究生。他们将完成必修课和选修课，并完成一项研究项目，其中包括使用分子生物学技术、分离组织、整个动物或临床研究。主要目标是向受训者提供如第147页所概述的跨学科基础科学和转化研究方面的广泛基础。学员将培养批判性思维、综合推理和技术技能，以创造和参与与预防和控制高血压、中风和呼吸系统疾病相关的不断发展的研究事业。一个创新的特点是强调解决国家需要为后基因组时代的生物医学研究的更综合系统的未来进行培训。研究训练由初级生理学教师以及其他基础科学和临床教师的共同导师监督。该计划将培训生物医学科学家进行研究和教育医疗专业人员，以发现和交流预防和管理心血管和肺部疾病所需的信息。

Description (provided by applicant): Over the last twenty years, training in Physiology departments throughout the country has undergone a transformation that precludes students from a thorough understanding that spans the breadth of the discipline from the whole animal to the cellular and molecular level. An exception is the Physiology Department of the Medical College of Wisconsin (MCW), that offers research training emphasizing integration of knowledge at all these levels with development of an appreciation for the relationship of this knowledge to disease processes. With the current proposal, we will continue providing this exceptional training in cellular, molecular, and whole animal physiology for 6 NIH supported trainees each year. A unique aspect of the proposed training is the mentoring program, which includes basic scientists from a variety of traditional areas as well as clinican scientists. Graduate students will be recruited nationally and selected on the basis of undergraduate academic credentials, research experience, and commitment to a career in research and training. Students complete the first year of graduate school before they will be considered for NIH training support. Selection of trainees will be based primarily on performance in course work and in the research laboratory during the first year of graduate school. Trainees are full-time Ph.D. candidates in the MCW graduate school of biomedical sciences. They will complete required and elective courses and a research project that includes use of the techniques of molecular biology, isolated tissues, and whole animal or clinical investigation. The major objective is to provide trainees with a broad foundation in interdisciplinary basic science and translational research as outlined on page 147. Trainees will develop the critical thinking, integrative reasoning, and technical skills required to create and participate in evolving research careers related to prevention and control of hypertension, stroke, and respiratory diseases. An innovative feature is the emphasis on addressing the national need to train for the more integrated-systems future of biomedical research in the post-genome era. Research training is supervised by primary Physiology faculty along with co-mentors from other basic science and clinical faculty. The program will train biomedical scientists to conduct research and educate medical professionals leading to the discovery and communication of information required for the prevention and management of cardiovascular and pulmonary disease.