Molecular basis of Ca2+-dependent disruption of EC-coupling and weakness in skeletal muscle

骨骼肌无力的一个主要原因似乎是控制钙离子从内部储存中释放并随之收缩的机制受到损害。该项目研究了损伤是否由于细胞内钙离子水平过高而引起的，这些钙离子激活酶切断了控制钙释放的特定重要分子。这一发现可以确定肌肉萎缩症和其他疾病中肌肉无力的主要因素，并导致特定的治疗方法。

One major cause of weakness in skeletal muscle appears to stem from damage to the mechanism controlling release of calcium ions from internal stores and consequent contraction. This project examines whether the damage is due to excessive levels of intracellular calcium ions activating enzymes that cut a particular vital molecule controlling calcium release. The findings could identify a major factor in muscle weakness in muscular dystrophy and other conditions and lead to specific therapies.