Irradiation

在过去提交的材料中，NCCC辐射共享资源的主要功能是为各种实验条件提供电离辐射，包括细胞、整个动物的辐射(免疫抑制)和啮齿动物肿瘤的治疗。虽然这些服务仍在继续，但新的重点是向达特茅斯研究社区提供诊断和成像技术以及最先进的放射治疗计划能力。具体地说，我们增加了使用keV/正电压X射线、MeV直线加速器和高剂量率(1921r)治疗照射的能力。资源人员还在使用激光治疗方面拥有丰富的经验和专业知识，如光动力疗法(PDT)。关于基于研究的成像应用程序，我们增加了专门的 数字透视、计算机断层扫描、诊断超声和活体荧光成像。这些增加极大地拓宽了辐射共享资源的范围。这项增加的技术将对NCCC的研究界带来巨大的好处，特别是在临床前和基于动物的翻译研究方面。

In past submissions the NCCC Irradiation Shared Resource has had the primary function of providing ionizing radiation for a variety of experimental conditions, including the irradiation of cells, whole animals (immunosuppression), and treatment of rodent tumors. Although these services continue, there is new emphasis on providing diagnostic and imaging technology and state-of-the-art radiation treatment planning capabilities to the Dartmouth research community. Specifically, we have added the use of KeV/orthovoltage x-ray, MeV linear accelerator and high-dose-rate (1921r) treatment irradiation capabilities. The Resource personnel also have significant experience and expertise in the use of laser-based treatments such as photodynamic therapy (PDT). Concerning research-based imaging applications, we have added dedicated digital fluoroscopy, computed tomography, diagnostic ultrasound, and in vivo fluorescent imaging. These additions have significantly broadened the focus of the Irradiation Shared Resource. The added technology will be of great benefit to the NCCC research community, especially in terms of preclinical and animal-based translational research.