Informatics Core

核心D：信息学 为了最佳和有效地支持临床和转化研究，必须超越收集数据 从研究人员，并利用现代信息学的工具和专业知识。需求的范围，从 从基础科学家到以结果为基础的临床研究者， 软件、硬件和信息技术专业人员来开发和维护这些工具。成本 设备的快速发展、技术发展的快速步伐以及适当地 如果没有高质量和高效率的信息学，就不可能管理MSCP的信息学需求 服务因此，这一资源必须得到很好的支持，并纳入研究使命 UPCI和MSCP的特殊需求。MSCP的信息学核心由 以下综合服务： 1)临床试验管理应用程序（CTMA）-支持MSCP和UPCI的所有临床试验， 整合到癌症登记处，组织库信息系统和器官特异性数据库。; 2)组织库信息系统-支持病理注释和库存控制 UPCI研究人员的生物标本（组织、血液、血清和体液）要求 3)登记信息服务-支持所有患者的临床和结局注释， 临床试验和谁贡献他们的癌症组织的组织库 4)诚实的经纪人服务-一个重要的组成部分，为符合HIPAA的研究信息服务 5)存储、存档和网络服务-支持强大的组织网络和存储解决方案 银行、成像、基因组和蛋白质组数据存档。三层备份服务（在线、近线和 远程）。 6)caBIG集成和数据共享-支持caBIG组织库工具支持，用于基因组的caArray 数据和符合NCI caBIG标准的数据共享计划，以协调MSCP的所有项目和核心。 MSCP将越来越依赖于提供强大的研究信息服务， 支持从实验室到床边的创新转化，并利用关键的临床和 临床结果数据来指导实验室的发现。Becich博士，这个核心的领导者，也是 生物医学信息学新资助的临床和转化科学研究所的核心领导人 匹兹堡大学以及UPCI癌症中心支持补助金的癌症信息学核心 （CCSG）。与NIH路线图计划和UPCI的这种额外整合是 皮肤癌孢子的信息学核心D。

CORE D: Informatics To optimally and efficiently support clinical and translational research, one must go beyond gathering data from researchers, and utilize the tools and expertise of modern informatics. The spectrum of needs, from those of a basic scientist to those of an outcomes-based clinical researcher requires a robust architecture of software, hardware, and information technology professionals to develop and maintain these tools. The cost of equipment, the rapid pace of technology development and the specialized expertise required to properly manage the informatics needs of the MSCP are not possible without high quality and efficient informatics services. It is therefore critical that this resource be well supported and integrated into the research mission of UPCI and the particular needs of the MSCP. The Informatics Core of the MSCP is composed of the following integrated services: 1) Clinical Trials Management Application (CTMA) - supports all clinical trials of the MSCP and UPCI with integration to the Cancer Registry, Tissue Banking Information Systems and Organ Specific Databases. ; 2) Tissue Banking Information System - supporting pathologic annotation and inventory control of the biospecimen (tissue, blood, serum and body fluids) requests of UPCI researchers 3) Registry Information Services - supporting all of the clinical and outcomes annotation of patients in clinical trials and who contribute their cancer tissues to the tissue bank 4) Honest Broker Services - an important component for HIPAA compliant research information services 5) Storage, Archival and Network Services - support robust network and storage solution for tissue banking, imaging, genomic and proteomic data archiving. Three tier backup services (on-line, near-line & remote) are provided. 6) caBIG integration and data sharing - supporting caBIG tissue bank tools support, caArray for genomic data and a NCI caBIG compliant data sharing plan in coordination for all projects and cores of the MSCP. MSCP will be increasingly reliant on the provision of robust research information services, to more effectively support the translation of innovation from the laboratory to the bedside and to utilize critical clinical and outcomes data in the clinic to guide discovery at the bench. Dr. Becich, leader of this core, is also the Biomedical Informatics Core leader for the newly funded Clinical and Translational Science Institute at the University of Pittsburgh as well as the Cancer Informatics Core of the UPCI's Cancer Center Support Grant (CCSG). This additional level of integration with NIH Roadmap Initiatives and the UPCI is a key strength of the proposed Informatics Core D of the Skin Cancer SPORE.