Developmental Research Program

发展研究计划(DRP)的目的是刺激人的初始、发展和 实施匹兹堡大学皮肤癌孢子创新研究。UPCI部已经 赞助了大量黑色素瘤和皮肤癌计划的发展研究 (MSCP)在过去20年中，随着对这些癌症感兴趣的新教员 招募并需要引人注目的新研究概念或基础设施来支持这些 努力。作为皮肤癌孢子应用程序的一个重要组成部分，我们建议转向更多 正式和定期的试点项目计划。DRP的具体目标是： 1.为了刺激与黑色素瘤和其他皮肤癌有关的新研究概念的启动， 展示了发展为完整的、将被赞助的翻译研究项目的前景 可能被皮肤癌孢子感染 2.促进已应用的现有翻译研究概念的发展 成功治疗其他肿瘤/疾病，但尚未应用于黑色素瘤或其他 皮肤癌，预计将发展为完全的项目，由 皮肤癌孢子 3.促进可能产生预期赞助的完整项目的研究的发展 由孢子 4.提高孢子基础和临床研究活动的知名度，以增加 一方面是基础科学家的参与，另一方面是临床医生和患者的参与， 从而加强了孢子的研究工作 我们打算利用孢子DRP来补充现有的资助机制，这些机制可供 UPCI和整个匹兹堡大学的科学和临床研究社区，包括 UPCI的试点赠款计划，最近发起的希尔曼基金会创新癌症研究员 研究计划、UPMC的竞争性医学研究基金和部门研究支持。 为实现这些目标，已承诺提供150 000美元的机构支助，以提供足够的资金 每年同时为两个发展方案提案提供资金(即每个项目75,000美元)。奖项将是 为期一年，有可能进行第二年的竞争性续签，等待取得重大进展 在最初的支持期间做出的决定。

The purpose of the Developmental Research Program (DRP) is to stimulate the initiation, development and implementation of innovative research within the University of Pittsburgh Skin Cancer SPORE. The UPCI has sponsored a substantial amount of developmental research in the Melanoma and Skin Cancers Program (MSCP) over the past 20 years on an ad hoc basis, as new faculty with interests in these cancers have been recruited and as compelling new research concepts or infrastructure has been required to support these efforts. As an important component of this application for a Skin Cancer SPORE, we propose to shift to a more formal and regular pilot project program. The Specific Aims of the DRP are: 1. To stimulate the initiation of novel research concepts related to melanoma and other skin cancers, that exhibit promise for development into full, translational research projects to be sponsored prospectively by the Skin Cancer SPORE 2. To stimulate the development of existing translational research concepts that have been applied successfully to other neoplasms/diseases, but that have not yet been applied to melanoma or other skin cancers, and which would be expected to develop into full projects sponsored prospectively by the Skin Cancer SPORE 3. To facilitate the development of research that may yield full projects to be sponsored prospectively by the SPORE 4. To increase the visibility of the SPORE'S basic and clinical research activities in order to increase the participation of basic scientists on the one hand, and clinicians and patients on the other, thereby fortifying the SPORE'S research efforts We intend to utilize the SPORE DRP to complement existing funding mechanisms that are available to the scientific and clinical investigation community of the UPCI and the University of Pittsburgh at large, including the UPCI's pilot grant program, the recently initiated Hillman Foundation Fellows in Innovative Cancer Research program, the Competitive Medical Research Fund of the UPMC, and departmental research support. To accomplish these goals, $150,000 of institutional support has been committed to provide sufficient levels for funding to underwrite two concurrent DRP proposals per year (i.e., $75,000 for each project). Awards will be made for one year, with the possibility for competitive renewal for a second year, pending significant progress made during the initial period of support.