Molecular characterization of dengue virus fusion and antiviral inhibitors.

登革热病毒由蚊子传播，在包括澳大利亚在内的世界100多个国家引起重大流行病。感染登革热病毒会导致严重的，有时甚至是致命的疾病。该提案的重点是登革热病毒进入细胞的方式以及阻止病毒进入的药物的开发。我们已经确定了抑制登革热进入细胞过程的化合物，该项目将大大建立在这些早期发现的基础上。

Dengue viruses are transmitted by mosquitoes and cause major epidemics in more than 100 countries around the world, including Australia. Infection with dengue viruses cause severe and sometimes fatal disease. This proposal focuses on the way dengue virus enters cells and the development of drugs that will prevent virus entry. We have already identified compounds that inhibit the entry process of dengue into cells and this project will significantly build on these early findings.