A FESIBILITY STUDY OF A BESREST ANALOG FOR LUNAR EXPLORATION (JSC/UTMB)

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是进行一项研究，表明可以通过使用月球/月球卧床模拟来模拟月球/月球使命。 这项研究试图建立一个真实的情况，以了解月球重力对宇航员在月球上的生理变化的影响。 参与这项研究可以持续6-8周，包括三个阶段-睡前休息阶段、卧床休息阶段（包括以9.5度的头向上倾斜卧床休息6天）和卧床休息后阶段（包括再调节）。在UTMB前时间（BR-30至BR-4）期间，布鲁斯跑步机测试将评估受试者的睡前有氧健身水平。 记录活动和持续时间的每日活动日志将在此期间完成7天。 将在进入UTMB后卧床前开始时和卧床结束时进行一次MRI检查，以确定腿部肌肉体积。 将在进入UTMB后卧床前开始时和卧床结束时进行一次血浆容量检测。 舒适度评估日志将在卧床休息阶段每天三次记录受试者的舒适度水平。 美国宇航局的科学家希望获得的信息将确定这项研究是否可以建立一个真实的情况，以了解月球重力对宇航员在月球上的生理变化的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research is to perform a study that shows it is possible to simulate a lunar/moon mission by using a lunar/moon bed rest analog. This study is trying to establish a real-life situation for understanding the effects of lunar gravity on physiological changes while astronauts are on the moon. Participation in this study may last 6-8 weeks and involves three phases - a before-bed rest phase, a bed rest phase (includes 6 days of bed rest at 9.5-degree of head-up tilt), and an after-bed rest phase (includes reconditioning).During the pre- UTMB time (BR-30 to BR-4) the Bruce Treadmill Test will assess the pre-bed rest level of aerobic fitness of subjects. The Daily Activity Log which records activities and duration will be completed for 7 days during this period. The MRI test will be used to determine leg muscle volumes once at the start of pre Bed-Rest after admission to UTMB and once at the end of Bed Rest. The Plasma Volume test will be performed once at the start of pre Bed-Rest after admission to UTMB and once at the end of Bed Rest. The Comfort Assessment Log will record comfort level of test subjects three times a day during the Bed Rest Phase. NASA scientists hope to get information that will determine if this study can establish a real-life situation for understanding the effects of lunar gravity on physiological changes while astronauts are on the moon.