CNS HIV ANTIRETROVIRAL EFFECTS RESEARCH (CHARTER)

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 CHARTER计划的目的是研究神经艾滋病的演变性质，特别是现代艾滋病毒药物的使用。 该研究设计为5年计划（2002-2007），延长3年（2007-2010）。这三年被视为收集更多数据的机会。研究人员有兴趣了解更多有关HIV相关神经系统疾病的信息，并将在未来3年内每6个月在6个研究中心收集约300人的详细医疗、实验室、心理和精神病史和评估。这些信息将帮助他们了解抗逆转录病毒药物（HAART）是否以及如何影响艾滋病毒感染者的神经系统疾病和损伤（如痴呆或周围神经病变）的并发症或预防。 研究人员还对HAART对经常发生的代谢变化的影响感兴趣，即，身体脂肪的损失或重新分配。 第二个问题是HAART和精神病药物如何相互作用。研究参与者将被要求每6个月进行一次测试。 基本测试将包括神经系统检查，神经心理学评估，精神病史，血液收集和腰椎穿刺。 其他测试可能包括神经传导研究，定量感觉测试，MRI和/或皮肤活检。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aim of the CHARTER Program is to examine the evolving nature of neuroAIDS, particularly with modern HIV medication use. The study was designed as a 5-year program (2002-2007) with a 3-year extension (2007-2010). This three year period was seen as an opportunity to gather additional data. The Investigators are interested in learning more about HIV-associated neurological disease and will collect detailed medical, laboratory, psychological and psychiatric histories and evaluations over the next 3 years on approximately 300 people, every six months at the 6 sites. This information will help them understand if and how anti-retroviral medications (HAART) affect the complication or prevention of neurological disease and impairment (such as dementia or peripheral neuropathy) in those infected with HIV. Researchers are also interested in the effect HAART has on the metabolic changes that often occur, i.e., loss of or redistribution of body fat. A secondary concern is how HAART and psychiatric medications interact. Study participants will be asked to undergo testing every 6 months. Basic testing will include neurological examination, neuropsychological evaluation, psychiatric history, blood collection, and a lumbar puncture. Additional testing may include nerve conduction studies, quantitative sensory testing, MRI, and or skin biopsy.