ACE UNIT BODY COMPOSITION STUDY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 缺乏体力活动与瘦体重和功能能力的加速丧失有关。我们的初步数据显示，与28天卧床休息的年轻人相比，老年人在卧床10天时瘦腿质量的损失是后者的3倍。此外，在健康的年轻志愿者中，缺乏运动和模拟压力(高皮质醇血症)的联合分解代谢侮辱导致的瘦肌肉质量损失比单独不活动的肌肉质量损失高300%。这些数据突显了在住院的身体丧失能力的老年人中肌肉质量和功能能力灾难性丧失的可能性。该项目的具体目标是量化老年患者群体在UTMB急性老年护理(ACE)单位住院期间所经历的肌肉损失的程度。身体成分数据(肌肉和脂肪质量)将在入院时和出院前(通常为3-6天)使用双能X射线吸收测量仪(DEXA)获得。这些描述性数据随后将被用于支持NIH拨款申请，重点是减少肌肉损失和改善功能恢复的针对性干预。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Physical inactivity is associated with the accelerated loss of lean body mass and functional capacity. Our preliminary data demonstrate a 3-fold greater loss of lean leg mass in older individuals during 10 days of bed rest, compared to a cohort of younger adults during 28 days of bed rest. Further, in healthy young volunteers, the combined catabolic insults of physical inactivity and simulated stress (hypercortisolemia) resulted in a 300% greater loss of lean muscle mass than inactivity alone. These data highlight the potential for catastrophic loss of muscle mass and functional capacity in physically incapacitated, hospitalized older adults. The specific goal of this project is to quantify the magnitude of muscle loss experienced by an elderly patient population during a period of inpatient care in the Acute Care for Elders (ACE) Unit at UTMB. Body composition data (muscle and fat mass) will be obtained on admission and prior to discharge (typically 3-6 day period) using dual energy x-ray absorptiometry (DEXA). These descriptive data will be subsequently used to support NIH grant submissions focusing on targeted interventions to reduce muscle loss and improve functional recovery.