EXERCISE TO REDUCE OBESITY IN SPINAL CORD INJURY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们的假设是，无论是功能性电刺激腿部周期测功术(FES LCE)运动还是自愿手臂曲柄测功术(ACE)上肢运动都会增加全身能量消耗，从而增加肌肉质量、胰岛素敏感性、骨密度，并改善截瘫成人患者的血脂状况。 与上肢(ACE)运动相比，FES LCE预计会对这些e参数产生更大的变化，因为总的下肢肌肉质量更大，肢体肌肉的收缩将增加下肢静脉血流量，增加左心室舒张末期容量、心输出量和随后的运动耐量

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. It is our hypothesis that both Functional Electrical Stimulation Leg Cycle Ergometry (FES LCE) exercise and voluntary Arm Crank Ergometry (ACE) upper extremity exercise will increase whole body energy expenditure, thereby increasing muscle mass, insulin sensitivity, bone mineral density and improving lipid profiles in adults with paraplegia. FES LCE is anticipated to result in greater changes for these e parameters than upper extremity (ACE) exercise because total lower extremity muscle mass is greater and contraction of lower extremity musculature will increase lower extremity venous blood flow, increasing left ventricular end diastolic volume, cardiac output and subsequently exercise tolerance