University of South Florida Application for Improving Animal Resources

描述(由申请人提供)：申请支持位于2005年2月占用的大学附属H.Lee Moffitt癌症中心和研究所新的稳定研究大楼(SRB)的大学老鼠屏障设施中急需的可移动设备。该设施的建立是为了应对1996年以来动物护理和使用服务需求的803%增长，这主要是由于转基因小鼠数量增加了1183%。AAALAC认证的中央管理的现有动物设施的能力 在坦帕湾，所有的研究都缺乏安全的微生物屏障，使研究面临因感染暴露而无效的风险。SRB老鼠屏障设施位于联邦政府资助的涉及老鼠的研究的最大焦点附近，并且毗邻坦帕湾历史上最大的研究实验室扩建。该设施建立了6,231 NSF额外的小鼠住房空间，一个专门用于小鼠模型核心的实验室，一个专门用于小鼠病理核心的尸检，以及一套用于活体小鼠成像核心的实验室，所有这些都在严格的微生物安全环境中。需要超过17,640个微隔离器来容纳多达70,560只小鼠。请提供支持以购买所需的11%的鼠标微隔离器，或16个单独通风的小鼠微隔离器架、8个相关的空气处理器、140个额外的笼架和5个运输架。所要求的可移动设备的净收益将用于由使用这一区域资源的八个附属机构的科学家指导的国家认可的生命科学研究。

DESCRIPTION (provided by applicant): Support is requested for movable equipment critically needed in the University's Mouse Barrier Facility located in the new Stabile Research Building (SRB) of the University-affiliated H. Lee Moffitt Cancer Center and Research Institute occupied in February 2005. This facility was established in response to an 803% increase in animal care and use service demands since 1996, due principally to an 1183% increase in the number of genetically engineered mice. Capacities of existing animal facilities of this centrally administered, AAALAC accredited program in Tampa Bay had been exceeded, and all lacked a secure microbiological barrier, placing studies at risk of being invalidated due to infectious exposures. The SRB Mouse Barrier Facility is ideally located near the greatest focus of federally funded research involving mice, and adjacent to the largest research laboratory expansion in Tampa Bay history. The facility established 6,231 nsf of additional mouse housing space, a dedicated laboratory for the Mouse Models Core, a dedicated necropsy for the Mouse Pathology Core, and a suite of laboratories for the In Vivo Mouse Imaging Core, all in a setting of stringent microbiological security. More than 17,640 microisolators are needed to house up to 70,560 mice. Support is requested to purchase 11% of the needed mouse microisolators, or 16 individually ventilated mouse microisolator racks, 8 associated air handlers, 140 additional cage setups and 5 transport racks. The net benefit of the movable equipment requested would accrue to nationally recognized life science research directed by scientists from eight affiliated institutions that use this regional resource.