Real Time Intraoperative SDOCT for Vitreoretinal Surgery

描述(由申请人提供)：我们建议开发一个SDOCT手术显微镜系统，用于检测、处理和向外科医生呈现数字图像。目前的外科医生通过双目显微镜观察视网膜的能力受到人眼在手术过程中解析精细结构的能力以及人类视觉系统从眼睛的立体视图估计深度的能力的限制。具有改进的眼内结构横截面分辨率的SDOCT输出将通过与当前手术观察方法兼容的平视显示器实时提供给外科医生。将开发图像处理算法来评估眼底视频和SDOCT图像参数，以向外科医生提供关于视网膜结构和手术器械的相对位置的实时反馈，并控制关键区域SDOCT图像数据的自适应采样。该项目的具体目标是：(1)将最先进的高速SDOCT技术应用于玻璃体视网膜手术；(2)应用新的图像处理概念，开发适用于玻璃体视网膜手术的实时SDOCT成像和分析的自适应框架；以及(3)将手术需求与SDOCT技术相结合，用于术中使用，在实验室和手术室测试并提供术中系统的反馈。公共卫生相关性：我们建议开发一种改进的手术显微镜系统，使用光谱域光学相干断层扫描技术来检测、处理数字图像并将其呈现给外科医生。具有改进的眼内结构横截面分辨率的数字输出将通过与当前手术观察方法兼容的平视显示器实时提供给外科医生。

DESCRIPTION (provided by applicant): We propose to develop an SDOCT surgical microscope system for detection, processing, and presentation of digital images to the surgeon. The current surgeon's view of the retina through a binocular microscope is limited by the ability of the human eye to resolve fine structures during surgery and by the ability of the human visual system to estimate depth from a stereoscopic view of the eye. The SDOCT output with improved resolution of intraocular structures in cross section will be provided to the surgeon in real time through a heads-up display that is compatible with current surgical viewing methods. Image processing algorithms will be developed to evaluate fundus video and SDOCT image parameters to provide real-time feedback to the surgeon regarding the relative position of retinal structures and surgical instruments, and also to control adaptive sampling of the SDOCT image data in critical regions. The specific aims of the project are to: (1) Adapt state-of-the-art high-speed SDOCT technology for intraoperative use in vitreoretinal surgery; (2) Apply new image processing concepts to develop an adaptive framework for real-time SDOCT imaging and analysis with applications in vitreoretinal surgery; and (3) Integrate surgical needs with SDOCT technology for intraoperative use, test and provide feedback on the intraoperative system both in laboratory and then in the operating room. PUBLIC HEALTH RELEVANCE: We propose to develop an improved surgical microscope system using spectral domain optical coherence tomography technology for detection, processing, and presentation of digital images to the surgeon. The digital output with improved resolution of intraocular structures in cross section will be provided to the surgeon in real time through a heads-up display that is compatible with current surgical viewing methods.