African Descent and Glaucoma Evaluation Study (ADAGES)

青光眼在黑人中发生的可能性是白人的5倍，是不可逆转的主要原因 黑人中的失明。关于包括视觉功能在内的新的诊断测试是否具有特异性，人们知之甚少 检查和视盘和视网膜神经纤维层成像可以提高我们的检测和监测能力 黑人人群中的青光眼。目的：系统地评估和比较新的诊断技术 黑白参赛者。目的：比较视功能测试和视觉功能测试结果的差异。 正常、高眼压和青光眼黑白患者的视神经结构 确定功能特定视野测试是否显示黑人的诊断能力像白人一样得到改善， 并比较两个种族的青光眼损害的发展速度和模式！ 研究对象：125名正常人和275名患有青光眼的黑人。方法：黑人参与者将是 主要从纽约眼耳医院和阿拉巴马大学青光眼服务中心招募。 加州大学圣地亚哥分校的白人参与者是在单独的资金支持下招募的。加州大学圣地亚哥分校是一家阅读公司 数据处理、质量控制和分析中心为本研究。青光眼的眼睛会 随后每年进行5年的检查。视野将包括标准临床视野检查和两个 特定功能测试、短波自动视野测量和倍频技术 周界勘测。视神经结构将用立体眼底照相和 定量应用海德堡视网膜断层扫描仪和光学相干断层扫描仪的比较 《在黑人和白人之间》将在每一次测试中以及在功能和结构的测量之间进行。 重要性：在研究结束时，从业者应该了解视觉功能和 白人和黑人患者的视神经结构及其在解释视神经结构时的作用 结果。更好地理解种族对青光眼发展和进展的重要性将 这一结果为未来针对这一高危少数群体的临床试验提供了更准确的终点。

Glaucoma, which is 5 times more likely to occur in Blacks than Whites, is the leading cause of irreversible blindness in Blacks. Little is known about whether new diagnostic tests including vision function specific tests and optic disc and retinal nerve fiber layer imaging can improve our ability to detect and monitor glaucoma in the Black population.Purpose: To systematicallyassess and compare new diagnostic techniques in Black and White participants. Aims: To compare differences in visual function tests and me^ures of optic nerve structure in normal, ocular hypertensive, and glaucomatous Black and White participants,to determine whetherfunction specific perimetry tests show improved diagnosis in Blacks as they do in Whites, and to^compare the rate and patterns of progression of glaucomatous damage in the two racial groups! Participants: 125 normal and 275 Black participants with glaucoma. Methods: Black participants will be recruited primarilyfrom New York Eye and Ear Infirmary and the University of Alabama Glaucoma Service. White participants are recruited under separate funding at UC San Diego. UC San Diego serves as aReading Center for data processing, quality control and analysis for this study. The glaucomatous eyes will be followed with annual testing for 5 years. Visual fields will include standard clinical perimetry, and two function-specific tests, Short-wavelength Automated Perimetry and Frequency Doubling Technology Perimetry. Optic nerve structure will be qualitatively evaluated with stereoscopic fundus photography and quantitatively using the Heidelberg Retina Tomograph and Optical Coherence Tomograph.Comparisons between Blacks and Whites will be made on each test and between the measures of function and structure. Importance: At study conclusion,practitioners should understand any differences in visual function and optic nerve structure between White and Black patients and how to account for them when interpretingthe results. A greater understandingof the importanceof race for development and progression of glaucoma will result leading to more precise endpointsfor future clinical trials with this at-risk minority population.