EFFECT OF RELOCATION ON NIGHTTIME ACTIVITY AND STRESS RESPONSES IN MACAQUES

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 SIB是一个严重的人类健康问题，在青少年和年轻人中呈上升趋势。一小部分正常饲养、单独圈养的成年雄性恒河猴自发发生SIB。在这个子项目中，我们研究了搬迁压力对有和没有SIB的恒河猴行为和下丘脑-垂体-肾上腺功能的短期和长期影响。 这些猴子被安置在一栋老建筑里的从地板到天花板的围栏里很多年了。 当这座建筑被重新检查并被预定拆除时，猴子们被转移到了一座新的建筑里。 由于猴子被关在不同的笼子里，而且不熟悉猴子，所以搬家预计会有压力。 在白天和晚上进行行为评估，血浆，唾液和头发的样本收集之前，之后立即，1年后的移动。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SIB is a significant human health problem which is on the rise among teenagers and young adults. A small percentage of normally reared, individually housed adult male rhesus monkeys spontaneously develop SIB. In this subproject, we examined the short- and long-term effects of a relocation stress on behavior and hypothalamic-pituitary-adrenal function in rhesus monkeys with and without SIB. The monkeys had been housed for many years in floor-to-ceiling pens in an old building. When the building was reexamined and slated for demolition, the monkeys were moved to a new building. Because the monkeys were housed in rooms with different caging arrangements and unfamiliar monkeys, the move was expected to be stressful. Behavioral assessments were conducted during daylight and evening hours, and samples of plasma, saliva, and hair were collected before, immediately after, and 1 year following the move.