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LENTIVIRAL VECTOR FOR GENE TRANSFER TO HEMATOPOIETIC STEM CELLS

LENTIVIRAL VECTOR FOR GENE TRANSFER TO HEMATOPOIETIC STEM CELLS
用于基因转移至造血干细胞的慢病毒载体
批准号：
7715576
负责人：
Donald B Kohn
金额：
$10.84万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
项目状态：
已结题
起止时间：
2008-05-01 至 2009-04-30
来源：
https://reporter.nih.gov/project-details/7715576
关键词：
AutologousBehavior TherapyBone Marrow TransplantationBusulfanComputer Retrieval of Information on Scientific Projects DatabaseFundingGene TransferGrantHematopoietic stem cellsHumanInstitutionLentivirus VectorResearchResearch PersonnelResourcesSourceStem cellsTransplantationUnited States National Institutes of Healthconditioningcytotoxic

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中文摘要
翻译
这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：研究预处理（白消安）对自体转基因造血干细胞移植的影响。白消安产生早期干细胞的特定损失，并且在人类骨髓移植之前被用作干细胞细胞毒性调节剂。
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: These studies focus on conditioning therapy (busulfan) for transplant of autologous transduced hematopoietic stem cells. Busulfan produces a specific loss of early stem cells and has been used as a stem cell cytotoxic conditioning agent prior to bone marrow transplantation in humans.
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