CLINICAL TRIAL: MIND-BODY EXERCISE FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE: PI

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 慢性阻塞性肺疾病（COPD）是发病率和死亡率的主要原因。尽管药物和手术治疗取得了进展，但许多患者的日常活动受到严重限制。虽然运动经常被认为是治疗的重要组成部分，但对于运动的最佳类型和持续时间没有达成共识，并且坚持传统的运动计划是有问题的。太极拳是一种温和的冥想身心运动，专注于自我意识和有效的调节呼吸，可能为这一人群提供优势，可能非常适合条件差的COPD患者。 这项前瞻性、随机化的试点试验将调查与常规护理对照相比，定制的12周太极计划是否对COPD患者安全有益。本研究亦将评估太极拳运动的强度，探讨身心运动的心理和生理反应，并提供初步的成本估算。结果测量包括运动能力、健康相关的生活质量、情绪、肺功能测试、呼吸困难症状、COPD自我效能、心率变异性和自主神经张力。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Chronic obstructive pulmonary disease (COPD)is a major cause of morbidity and mortality. Despite advances in pharmacologic and surgical therapy, many patients suffer from substantial limitations in daily activities. Although exercise is often cited as an important component of treatment, there is no consensus on optimal type and duration of exercise, and adherence to conventional exercise program is problematic. Tai chi, a meditative gentle mind-body exercise with a focus on self-awareness and efficient, regulated breathing, may offer advantages to this population and may be well suited to poorly conditioned patients with COPD. This prospective, randomized pilot trial of 12 patients will investigate whether a tailored 12-week Tai chi program may be safe and beneficial for patients with COPD as compared to a usual care control. This study will also estimate Tai chi exercise intensity, explore psychosocial and physiological responses to mind-body exercise and provide preliminary estimates of cost. Outcome measurements include exercise capacity, health related quality-of-life, mood, pulmonary function tests, symptoms of dyspnea, COPD self-efficacy, heart rate varialibility and autonomic tone.