Mind-Body Exercise in the Management of Cardiac Disease

身心锻炼在心脏病治疗中的应用

• 批准号: 7012722
• 负责人: GLORIA Y YEH
• 金额: $ 13万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-01 至 2010-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7012722
• 关键词: acupuncture /acupressure; alternative medicine; cardiovascular disorder therapy; chiropractic; clinical research; emotions; functional ability; health behavior; health care service utilization; heart disorder; heart failure; human subject; meditation; patient oriented research; quality of life; rehabilitation; relaxation; self care; stress management

DESCRIPTION (provided by applicant): Dr. Gloria Yeh's long-term career goal is to become an independent clinician investigator focusing on the critical evaluation, mechanistic understanding, and successful integration of evidence-based complementary and alternative medical (CAM) therapies for patients with cardiovascular disease and heart failure. Her immediate career objectives are: to enhance her methodological skills in clinical trial design and health services research through coursework, educational seminars, and the development of three rigorous, mentored studies; to understand the potential psychosocial and physiological mechanisms by which mind-body exercise can improve clinical outcome in cardiac patients; and to define the potential role of mind-body exercise and other CAM modalities in the current management of patients with cardiovascular disease. This proposal includes three projects with a particular focus on mind-body exercise in patients with chronic heart failure. The first will be a secondary database analysis describing the patterns and prevalence of CAM use in a large national sample of patients with cardiac disease and examining the factors associated with perceived beneficial use of tai chi, qigong, or yoga. The second and main project will be a pilot randomized controlled trial (n=20) evaluating study feasibility and safety of a 12-week tai chi/qigong program in older patients with diastolic heart failure. This study will provide important preliminary data regarding potential psychosocial effects (e.g., change in self-efficacy, mood, quality-of-life) and physiological mechanisms (e.g., change in exercise capacity, autonomic tone, neurohormone status) in preparation for a future R01application for a larger randomized clinical trial. The third project will assess current cardiac rehabilitation programs available to patients with cardiovascular disease and heart failure to begin to explore the incorporation of mind-body exercise into these rehabilitation programs and to understand the perceived successful psychosocial program components (e.g., factors that can enhance patient self-efficacy and program adherence). Completion of the proposed research and career development activities will enhance Dr. Yeh's ability to conduct patient-oriented research and allow her to achieve her career goal of becoming an independent clinical researcher investigating CAM therapies and its applications to patients with cardiac disease.

描述（由申请人提供）：Gloria Yeh博士的长期职业目标是成为一名独立的临床研究者，重点是针对心血管疾病和心脏衰竭患者的批判性评估，机理理解和成功整合。她的直接职业目标是：通过课程，教育研讨会以及开发三个严格的，指导的研究，以提高她在临床试验设计和卫生服务研究方面的方法论技巧；要了解思维体运动可以改善心脏患者临床结果的潜在社会心理和生理机制；并定义心身运动和其他CAM模式在心血管疾病患者当前管理中的潜在作用。 该建议包括三个项目，特别关注慢性心力衰竭患者的思维体育运动。第一个将是一个辅助数据库分析，描述了大型全国性心脏病患者样本中CAM使用的模式和流行率，并检查了与Tai Chi，Kisigong或Yoga的有益使用相关的因素。第二个和主要项目将是一项试验随机对照试验（n = 20），评估研究的可行性和为期12周的TAI CHI/气功计划，该计划在老年患有舒张期心力衰竭的患者中。这项研究将提供有关潜在的社会心理影响（例如，自我效能，情绪，生活质量的变化）和生理机制（例如，运动能力的变化，自主性语调，神经激素状态的变化）的重要初步数据，以准备对未来的R01 Application进行大型随机临床试验。第三个项目将评估患有心血管疾病的患者可用的当前心脏康复计划，并且心脏无法开始探索思维体运动纳入这些康复计划，并了解感知到的成功的社会心理计划成分（例如，可以增强患者自我效能和计划的因素）。 拟议的研究和职业发展活动的完成将增强YEH博士进行以患者为导向的研究的能力，并使她能够实现自己的职业目标，即成为研究CAM疗法的独立临床研究人员，及其对心脏病患者的应用。