LONG-TERM PHYSIOLOGIC EFFECTS OF GH IN HIV LIPODYSTROPHY

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们假设，长期的，生理GH管理GH缺乏的HIV脂肪营养不良患者，定义的基础上，标准化的刺激测试的反应，将改善，胰岛素敏感性，心血管风险参数，骨密度和身体成分。 在一项随机、双盲、安慰剂对照研究中，我们将确定： A）长期生理GH给药对身体组成、骨密度和骨转换标志物、CV风险标志物（包括传统脂质水平和增加的CV风险的新型炎症标志物）和葡萄糖稳态的影响; B）GH停药后生理性GH治疗的效果是否持续。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We hypothesis that long-term, physiologic GH administration to GH deficient patients with HIV lipodystrophy, defined based on responses to standardized stimulation testing, will improve, insulin sensitivity, cardiovascular risk parameters, bone density and body composition. In a randomized, double-blinded, placebo-controlled study, we will determine: A)The effects of long-term physiologic GH dosing on body composition, bone density and markers of bone turnover, CV risk markers including traditional lipid levels and novel inflammatory marker of increased CV risk, and glucose homeostasis; B)Whether the effects of physiologic GH treatment are sustained after GH withdrawal.