CLINICAL TRIAL: MODULATION OF PREFRONTAL ACTIVITY TO IMPROVE LANGUAGE SKILLS IN

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目的目标是通过调节自闭症谱系障碍（ASD）患者的前额叶活动，使用1 Hz rTMS提高语言技能。 背景是基于我们先前的工作，证明（1）ASD患者具有异常的镜像神经元系统和布罗卡区的异常，以及（2）使用rTMS调节前额兴奋性改善失语症患者的语言。 该假设是，rTMS的应用程序，以右部三角将显着改善语言通过诱导快速可塑性和调制的有效连接，在双半球语言网络。 有两个阶段：第1阶段是一项四刺激部位、受试者内多交叉试验，旨在证明rTMS是安全的，并评估一次rTMS对ASD语言技能的影响。 只有在第一阶段证明安全并且我们的疗效假设得到证实的情况下，才会启动第二阶段。 这是一项平行组、假刺激对照的临床试验，旨在评估右侧三角部10次rTMS对语言的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of the project is to improve language skills using 1 Hz rTMS by modulating prefrontal activity in patients with autism spectrum disorders (ASD). The background is based on our prior work demonstrating that (1) patients with ASD have an abnormal mirror neuron system and abnormalities in Broca's area, and (2) modulation of prefrontal excitability using rTMS improves language in aphasic patients. The hypothesis is that application of rTMS to the right pars triangularis will significantly improve language through induction of rapid plasticity and modulation of effective connectivity in the bihemispheric language network. There are two phases: Phase 1 is a four-stimulation site, within-subject multiple crossover trial which aimed to show that rTMS is safe and to evaluate the effects of one rTMS session on language skills in ASD. Phase 2 will only be initiated if phase 1 proves safe and our efficacy hypothesis is confirmed. This is a parallel group, sham-stimulation controlled, clinical trial which aims to assess the impact of ten rTMS sessions to right pars triangularis on language.