THE NEURAL BASES OF NOUN AND VERB MEANINGS

名词和动词含义的神经基础

• 批准号: 7718947
• 负责人: Alvaro Pascual-Leone
• 金额: $ 0.03万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718947
• 关键词: Address; Area; Brain; Brain region; Comprehension; Computer Retrieval of Information on Scientific Projects Database; Disease; Failure; Functional Magnetic Resonance Imaging; Funding; Goals; Grant; Institution; Modality; Motor; Motor Cortex; Participant; Research; Research Personnel; Resources; Sensory; Social isolation; Source; Techniques; Temporal Lobe; Transcranial magnetic stimulation; United States National Institutes of Health; base; developmental disease; disability; relating to nervous system

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Words allow us to categorize the world and communicate with other people. Many acquired and developmental disorders are characterized by a failure to use words appropriately, resulting in disability and social isolation. Successful treatment of such disorders requires understanding of how the meanings of words are acquired and represented. Yet, despite extensive research, the neural base of word meanings remains a topic of contention. The goal of this proposal is to address an important point of controversy: whether word meanings are represented in a modality specific format (i.e. in secondary association areas). To achieve this goal, we will combine the complementary techniques of functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS). Combining these techniques will enable us to infer what brain regions are necessary for word comprehension. Participants will undergo fMRI while performing a word comprehension task. TMS will then be applied to the brain areas identified using fMRI to determine whether they are necessary for word comprehension. It is hypothesized that higher order regions (e.g. temporal lobe) but not sensory-motor regions (e.g. motor cortices) are necessary for word comprehension.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 词汇使我们能够对世界进行分类，并与其他人进行交流。 许多后天性和发育性障碍的特点是不能恰当地使用词语，导致残疾和社会孤立。 成功治疗此类疾病需要了解词语的含义是如何获得和表示的。 然而，尽管有广泛的研究，词义的神经基础仍然是一个争论的话题。 这一建议的目的是解决一个重要的争议点：词义是否表示在一个特定的模式（即在二级关联领域）。为了实现这一目标，我们将联合收割机结合功能磁共振成像（fMRI）和经颅磁刺激（TMS）的互补技术。 结合这些技术将使我们能够推断出哪些大脑区域是理解单词所必需的。 参与者将在执行单词理解任务时接受fMRI。 然后将TMS应用于使用fMRI识别的大脑区域，以确定它们是否是单词理解所必需的。 据推测，高阶区域（如颞叶），而不是感觉运动区域（如运动皮层）是必要的单词理解。