REPETITIVE TMS TO IMPROVE SPEECH IN APHASIA

重复 TMS 可改善失语症患者的言语

• 批准号: 7718886
• 负责人: Alvaro Pascual-Leone
• 金额: $ 0.08万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718886
• 关键词: Age; Aphasia; Area; Blood flow; Broca Aphasia; Computer Retrieval of Information on Scientific Projects Database; Enrollment; Functional Magnetic Resonance Imaging; Funding; Grant; Individual; Institution; Light; Motor Cortex; Names; Numbers; Patients; Population; Purpose; Research; Research Personnel; Resources; Source; Speech; Today; United States National Institutes of Health; Week; Work; chronic stroke; improved; interest; novel therapeutics; repetitive transcranial magnetic stimulation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The number of people with aphasia in the US today is estimated to be 1 million with 80,000 new cases each year. New therapeutic treatments are needed, especially in light of increases in the age of the US population. The purpose of this study is to investigator whether repetitive transcranial magnetic stimulation (rTMS) can be used to improve speech in chronic stroke patients with nonfluent aphasia. Previous work using fMRI has identified excess blood flow (presumed abnormal increase in cortical excitability) in certain areas of the right hemisphere in individuals with nonfluent speech. It is hypothesized that ten sessions of real rTMS at 1 Hz given over a two week period to the right motor cortex or other right hemisphere regions of interest specific for that aphasia patient, will significantly improve ability to name pictures and significantly improve propositional speech. Sham rTMS to the same regions of interest is hypothesized to have no effect. In addition to enrolling subjects with aphasia, a group of normal controls will also be enrolled in this study.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 今天美国失语症患者的数量估计为100万，每年有8万例新病例。 需要新的治疗方法，特别是考虑到美国人口年龄的增加。 本研究的目的是探讨重复经颅磁刺激（rTMS）是否可以用于改善慢性脑卒中非流利性失语患者的言语。 先前使用功能磁共振成像的研究已经发现，在言语不流利的个体中，右半球的某些区域存在过多的血流量（推测为皮层兴奋性的异常增加）。 假设在两周的时间段内以1 Hz对失语症患者的右运动皮层或其他右半球感兴趣的区域给予10次真实的rTMS，将显著改善命名图片的能力并显著改善命题言语。 假设对相同感兴趣区域的假rTMS没有影响。 除入组失语症受试者外，本研究还将入组一组正常对照。