Transcranial Stimulation in Spino-Cerebellar Ataxia

脊髓小脑共济失调的经颅刺激

• 批准号: 8621719
• 负责人: Alvaro Pascual-Leone
• 金额: $ 25.4万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8621719
• 关键词: Biological Neural Networks; Biomechanics; Brain; Brain Part; Brain region; Cerebellar Ataxia; Cerebellar degeneration; Cerebellum; Clinical; Clinical Trials; Complex; Double-Blind Method; Electromagnetics; Equilibrium; Functional disorder; Future; Gait; Genes; Genetic; Guidelines; Hereditary Disease; Human; Individual; Intervention; Investigation; Knowledge; Lead; Limb Ataxia; Magnetic Resonance Imaging; Magnetism; Mental Depression; Mental disorders; Metric; Morbidity - disease rate; Movement; Multi-Institutional Clinical Trial; Muscle; Musculoskeletal Equilibrium; Neurodegenerative Disorders; Neuronavigation; Outcome; Paresis; Parkinson Disease; Parkinson' s Dementia; Patients; Peripheral Nerves; Pharmaceutical Preparations; Physiology; Pilot Projects; Plant Roots; Posture; Quality of life; Quantitative Evaluations; Randomized; Randomized Controlled Trials; Recruitment Activity; Resistance; Series; Spinocerebellar Ataxias; Stroke; Structure; Symptoms; System; Testing; Transcranial magnetic stimulation; Traumatic Brain Injury; Treatment Efficacy; Walking; balance testing; base; disability; evidence base; experience; falls; family genetics; follow-up; functional decline; functional disability; functional gain; functional improvement; functional outcomes; improved; improved mobility; motor control; nervous system disorder; neurophysiology; novel strategies; novel therapeutic intervention; public health relevance; repetitive transcranial magnetic stimulation; spinal tract

DESCRIPTION (provided by applicant): Spinocerebellar ataxia (SCA) refers to a family of genetic diseases that cause progressive problems with gait and balance, as well as other debilitating symptoms. Even though the genes responsible for many of the SCA subtypes are known, and even though we know that they all are associated with damage of the cerebellum and other specific parts of the brain, there is no cure for SCA and we still lack an effective symptomatic treatment. We propose a novel approach using noninvasive transcranial magnetic stimulation (TMS) to improve balance, gait, and posture in patients with SCA. We will recruit 20 patients with genetically-confirmed SCA. Half will be randomly assigned to a real intervention, and half to a sham (i.e., control) intervention. The TMS intervention will consist of 20 stimulatio sessions over a four week period. At baseline and at follow-up, all patients will undergo comprehensive assessments including several SCA rating scales, along with sophisticated tests of balance (i.e., walking, standing and muscle coordination). Patients will also complete a series of neurophysiologic tests to evaluate the function of the cerebellum and its connections before and after the intervention. This will help us test the clinical utility of the intervention and als gain new knowledge about the basis for the disability in SCA. In pilot studies we have shown already that TMS is safe when applied to the cerebellum and that it can improve balance in patients. We now will conduct a more systematic, larger, carefully controlled proof- of-principle clinical trial We anticipate that patients receiving real rTMS will show better balance, fewer falls, and improved mobility while those undergoing sham stimulation will show no benefits. If our prediction is correct, this study will provide evidence-based support for a new treatment to improve the lives of patients with SCA, and the proposed quantitative evaluations will examine possible objective end-points for a future, larger multi-site clinical trial.

描述（由申请人提供）：脊髓小脑共济失调（SCA）是一种遗传性疾病，可导致步态和平衡的进行性问题以及其他衰弱症状。尽管已知许多SCA亚型的基因，尽管我们知道它们都与小脑和大脑其他特定部位的损伤有关，但SCA没有治愈方法，我们仍然缺乏有效的对症治疗。我们提出了一种新的方法，使用非侵入性经颅磁刺激（TMS），以改善平衡，步态，并与SCA患者的姿势。我们将招募20名遗传学确诊的SCA患者。一半将被随机分配到真实的干预，另一半被随机分配到假干预（即，控制）干预。TMS干预将包括在四周内进行的20次刺激。在基线和随访时，所有患者将接受全面评估，包括几个SCA评定量表，沿着复杂的平衡测试（即，行走、站立和肌肉协调）。患者还将完成一系列神经生理学测试，以评估干预前后小脑及其连接的功能。这将有助于我们测试干预的临床效用，并获得有关SCA残疾基础的新知识。在初步研究中，我们已经表明，TMS应用于小脑是安全的，它可以改善患者的平衡。我们现在将进行一项更系统、更大、仔细控制的原理验证临床试验。我们预计，接受真实的rTMS的患者将显示出更好的平衡、更少的福尔斯和改善的活动性，而接受假刺激的患者将没有任何益处。如果我们的预测是正确的，这项研究将为改善SCA患者生活的新疗法提供循证支持，拟议的定量评估将为未来更大规模的多中心临床试验检查可能的客观终点。