ACETAMINOPHEN (TYLENOL?) INDUCED HUMAN LYMPHOCYTE TOXICITY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：本研究旨在进一步了解药物所致细胞损伤的可能机制。将获得来自健康志愿者的人类淋巴细胞。将在外周血淋巴细胞中进行体外实验，以评估受试者内和受试者之间对对乙酰氨基酚毒性的敏感性差异。 参与者：100名健康志愿者 程序(方法)：将使用体外细胞活性分析和流式细胞术来评估淋巴细胞对扑热息痛毒性的敏感性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Purpose: This study was designed to learn more about potential mechanisms of drug-induced cellular injury. Human lymphocytes from healthy volunteers will be obtained. In-vitro experiments will be carried out in peripheral lymphocytes to assess intra-subject and inter-subject variability in sensitivity to acetaminophen toxicity. Participants: 100 Healthy Volunteers Procedures (methods): In vitro cell viability assays and flow cytometry will be used to assess lymphocyte sensitivity to toxicity caused by acetaminophen