THE BENEFICIAL METABOLIC EFFECTS OF INTERMITTENT FASTING

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 建议将治疗性禁食的补充和替代医学实践作为肥胖和其他代谢性疾病的治疗方法。肥胖症目前是美国最严重的营养障碍，降低肥胖率是《2010年健康人》的主要目标。然而，尽管有这些目标，肥胖症的患病率仍在继续上升。肥胖症亟需新的治疗方案。传统卡路里限制的减肥和新陈代谢益处往往很小，而且持续时间很短。有强有力的数据支持通过治疗性禁食减肥的各种益处和持久性。然而，持续禁食是不切实际的，并增加了相关的不良事件。最近，动物数据表明，间歇性禁食(每隔一天)对新陈代谢的益处与长期禁食相似。也有数据表明，间歇性禁食比长时间禁食更安全，比传统的热量限制更容易忍受。这里描述的研究旨在检验这样一个总体假设，即治疗性间歇禁食(IF)将比适度每日热量限制(CR)更有效地治疗肥胖症。将实现以下具体目标： 1)确定IF和CR对体重减轻和身体成分的影响 2)探讨IF与CR对胰岛素敏感性、血脂水平和血压的影响 3)评价IF与CR的安全性和耐受性

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The both complementary and alternative medicine practice of therapeutic fasting is recommended as a treatment of obesity and other metabolic diseases. Obesity is currently the most significant nutritional disorder in the United States and a reduction in the prevalence of obesity is targeted as a major objective in "Healthy People 2010". However, despite these goals, the prevalence of obesity is continuing to rise. New treatment options for obesity are desparately needed. The weight loss and metabolic benefits of traditional caloric restriction tend to be small and short lived. There are strong data to support a variety of benefits and durability of weight loss with therapeutic fasting. However, persistent fasting is not practical and has increased associated adverse events. Recently, animal data suggests that intermittent fasting (every other day) has similar metabolic benefits to prolonged fasting. There are also data to suggest that intermittent fasting will be safer than prolonged fasting and easier to tolerate than traditional caloric restriction. The studies described herein are designed to test the overall hypothesis that therapeutic intermittent fasting (IF) will be a more effective treatment for obesity than moderate daily caloric restriction (CR). The following specific aims will be addressed: 1) To determine the effect of IF compared to CR on weight loss and body composition 2) To explore the effect of IF compared to CR on insulin sensitivity, lipid levels, and blood pressure 3) To evaluate the safety and tolerability of IF compared to CR