Prospective/Retrospective Motion Correction System for Motion Robust Pediatric MR

描述（由申请人提供）：用于运动鲁棒性儿科磁共振成像的跟踪MR硬件/软件系统本研究旨在开发改进的运动鲁棒性磁共振成像（MRI）技术。磁共振成像是一种强大的工具，既有助于诊断个体受试者，指导他们的临床护理，并提供洞察正常和非典型发展的机制。脑MRI促进了整个生命周期中精神健康障碍的表征。然而，传统的磁共振成像要求被成像的对象在图像编码的持续时间内保持完全静止。患有自闭症或结节性硬化症的幼儿和成人患者通常难以保持足够长的时间以进行成功的成像。对于临床成像，这些患者经常被镇静或麻醉，这冒着不良事件的风险，并且不能确保受试者保持完全静止。研究通常无法使用镇静或麻醉，因为可能会导致发病或死亡。这阻碍了我们识别精神健康障碍的神经生物学基础的能力。运动鲁棒磁共振成像的发展将使我们在绘制精神疾病的生命轨迹方面的能力得到显着提高。这将对我们确定何时、何地和如何进行干预的能力产生重大影响，并能够改进对潜在干预措施的评价。该项目是第一阶段SBIR，以响应计划公告“实验室到市场：大脑和行为研究工具”。该项目建议利用一种新颖的硬件组合进行运动跟踪和复杂的采集后处理，并进行分散的数据插值，以便能够从无法保持静止的受试者中构建高分辨率高信噪比的大脑图像。在本I期研究中，我们试图证明补偿头部刚体运动的能力，建立在我们先前在开发MRI兼容跟踪硬件和分散数据插值方面的工作基础上。将通过对健康志愿者和自闭症或结节性硬化症患者的实验来评估运动存在下的成功成像。公共卫生相关性：本研究旨在开发改进的运动鲁棒磁共振成像技术。改进后的成像技术将在波士顿儿童医院应用并评估其在儿童和成人高分辨率成像方面的功效。患有自闭症或结节性硬化症的幼儿和成人患者通常难以保持静止进行磁共振成像。这阻碍了我们识别精神健康障碍的神经生物学基础的能力。运动鲁棒磁共振成像的发展将使我们在绘制精神疾病的生命轨迹方面的能力得到显着提高。这将对我们确定何时、何地和如何进行干预的能力产生重大影响，并能够改进对潜在干预措施的评价。

DESCRIPTION (provided by applicant): A Tracked MR Hardware/Software System for Motion Robust Pediatric Magnetic Resonance Imaging This research aims to develop improved motion robust magnetic resonance imaging (MRI) technology. Magnetic resonance imaging is a powerful tool that both aids in the diagnosis of individual subjects, guides their clinical care, and provides insights into the mechanisms of normal and atypical development. The characterization of mental health disorders across the lifespan has been facilitated by brain MRI. However, conventional magnetic resonance imaging requires the subject being imaged remain perfectly still for the duration of the image encoding. Young children and adult patients with autism or tuberous sclerosis often have difficulty to hold still long enough for successful imaging. For clinical imaging such patients are frequently sedated or anesthetized, which runs the risk of adverse events, and does not ensure the subjects remain perfectly still. Research studies are typically unable to use sedation or anesthesia due to the possibility of morbidity or mortality. This hampers our ability to identify the neurobiological underpinnings of mental health disorders. The development of motion robust magnetic resonance imaging will enable dramatic improvements in our capacity to chart the trajectory of mental illness over the lifespan. This will have a significant impact on our ability to determine when, where and how to intervene, and enable improved evaluation of potential interventions. This project is a Phase I SBIR in response to the Program Announcement ''Lab to Marketplace: Tools for Brain and Behavioral Research''. The project proposes to utilize a novel combination of hardware for motion tracking and sophisticated post-acquisition processing with scattered data interpolation to enable the construction of high resolution high signal-to-noise ratio images of the brain from subjects who are unable to hold still. In this Phase I study we seek to demonstrate the capacity to compensate for rigid body motion of the head, building on our previous work in the development of MRI compatible tracking hardware, and scattered data interpolation. Successful imaging in the presence of motion will be evaluated through experiments with healthy volunteers and with patients with autism or tuberous sclerosis. PUBLIC HEALTH RELEVANCE: This research aims to develop improved motion robust magnetic resonance imaging technology. The improved imaging technology will be applied and evaluated for its efficacy at enabling high resolution imaging of children and adults at Children's Hospital Boston. Young children and adult patients with autism or tuberous sclerosis often have difficulty to hold still for magnetic resonance imaging. This hampers our ability to identify the neurobiological underpinnings of mental health disorders. The development of motion robust magnetic resonance imaging will enable dramatic improvements in our capacity to chart the trajectory of mental illness over the lifespan. This will have a significant impact on our ability to determine when, where and how to intervene, and enable improved evaluation of potential interventions.