Adaptation of Couples Voluntary Counseling and Testing (CVCT) for US MSM

描述（由申请人提供）：在美国，男男性行为者（MSM）的艾滋病毒感染率持续上升，2006年美国新增艾滋病毒感染者中有50%以上是男男性行为者。疾病预防控制中心最近的一项分析表明，男男性行为者中一半以上的艾滋病毒传播来自主要伙伴。因此，针对主要伙伴关系中的男男性行为者开发新的艾滋病毒预防措施应成为优先事项。夫妇艾滋病毒自愿咨询和检测（CVCT）被CDC描述为“高杠杆艾滋病毒预防干预”，与个人艾滋病毒咨询和检测相比，已被证明可以减少非洲妇女的艾滋病毒感染，并已向非洲夫妇提供了几十年。我们建议调整非洲CVCT干预措施以用于美国MSM，并进行一项小型可行性试验，以证明招募参与者参与该干预措施试验的可行性，证明美国MSM干预措施的安全性，并得出未来试验设计所需的关键参数估计值（如有指征）。将收集和分析焦点小组数据，以制定研究措施，并了解潜在客户和艾滋病毒预防顾问（最终将提供干预措施）对适应性干预措施的可接受性。适应的干预措施和适应的干预措施的评价将指导夫妇的相互依存的理论框架;充分评估在这个理论背景下的干预，我们还将开发和验证新的量表来衡量几个结构的理论（偏好的结果，夫妇的效能，结果效能，和感知的社会支持）。研究的预期成果是一个适合文化的夫妇艾滋病毒预防干预措施，初步数据，以支持可行性和设计未来的疗效试验，并验证规模，用于未来的试验和其他研究夫妇的干预措施。

Description (provided by applicant): HIV incidence among men who have sex with men (MSM) continues to rise in the United States, and over 50% of new US HIV infections in 2006 were among MSM. A recent CDC analysis suggests that over half of HIV transmissions among MSM are from main partners. Therefore, the development of new HIV preventions that target MSM in main partnerships should be a priority. Couples HIV Voluntary Counseling and Testing (CVCT) is described by CDC as a "high leverage HIV prevention intervention", has been shown to reduce HIV infections in African women when compared with individual HIV counseling and testing, and has been provided to African couples for decades. We propose to adapt the African CVCT intervention for use with US MSM, and conduct a small feasibility trial to demonstrate feasibility to enroll participants in a trial of this intervention, to demonstrate the safety of the intervention for US MSM, and to derive estimates of key parameters that will be required for design of future trials if indicated. Focus group data will be collected and analyzed to develop study measures and to understand acceptability of the adapted intervention to both potential clients and to HIV prevention counselors, who would eventually deliver the intervention. The adaptation of the intervention and the evaluation of the adapted intervention will be guided by the theoretical framework of the couple's interdependence; to fully evaluate the intervention in this theoretical context, we will also develop and validate new scales to measure several constructs of the theory (preferences for outcomes, couple efficacy, outcome efficacy, and perception of social support). Expected outcomes of the research are a culturally appropriate adapted HIV prevention intervention for couples, preliminary data to support feasibility and design of future efficacy trials, and validated scales for use in future trials and other research on couples' interventions.