ESTIMATING HUMAN ZINC PHYSIOLOGICAL ZINC REQUIREMENTS: TESTING A NEW CONCEPT

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 食品和营养委员会最近通过了一个基本上是关于人体如何调节锌的新概念，导致膳食锌需求量的估计大幅增加。 该提案的长期目标是实现人类锌需求量的准确计算-估计的平均个人膳食需求量（EAR）和推荐的膳食供给量（RDA）。 该建议将具体研究影响全身锌稳态的各种因素之间的相互关系，并将特别研究从饮食中吸收的锌量与粪便和尿液中消除的锌量之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Food and Nutrition Board recently adopted what was essentially a new concept of how the human body regulates zinc that resulted in a very major increase in estimates of dietary zinc requirements. The long-term goal of this proposal is to achieve accurate calculations of human zinc requirements - estimated average individual dietary requirements (EARs) and recommended dietary allowances (RDAs). This proposal will specifically examine the interrelationships between various factors affecting whole body zinc homeostasis, and will particularly examine the relationship between the amount of zinc absorbed from the diet and the amount of zinc eliminated in feces and urine.