CLINICAL TRIAL: EFFECT OF INTERNET-ENABLED INTENSE EXERCISE THERAPY ON MOTOR STA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 脊髓损伤(SCI)在美国仍然是一个主要的医疗问题。每年有超过11,000名新患者遭受新的SCI并存活下来(1)，美国的患病率接近25万。许多继发性的医学问题使脊髓损伤更加严重。以美元计算的终生成本在SCI患者的年龄不同，但对于大多数四肢瘫痪患者来说，成本超过100-200万美元。 在大约一半的脊髓损伤患者中，损伤被认为是完全的，这意味着脊髓损伤水平以下的任何运动或感觉功能都不受大脑控制，而仅仅是由反射或局部脊髓事件引起的。在另一半患者中，损伤是不完整的，这意味着只有一小部分正常的大脑对亚损伤脊髓事件的控制。 有几条证据表明，脊髓损伤后，行为缺陷往往比通过测量解剖损伤所预测的更严重。如果是真的，这表明在固定病变的情况下，即使在缺陷严重的情况下，也有可能改善运动状态。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Spinal cord injury (SCI) remains a major medical problem in the U.S. Over 11,000 new patients suffer and survive a new SCI each year(1), with U.S. prevalence of nearly a quarter million persons. SCI is compounded by numerous secondary medical problems. The lifetime cost in dollars varies with the age at SCI but exceeds 1-2 million dollars for most quadriplegics. In approximately half of all patients with SCI, the injury is said to be complete, meaning that none of the motor or sensory function below the level of SCI is controlled by the brain, instead arising solely from reflex or localized spinal cord events. In the other half of patients, injury is incomplete, meaning a fraction of the normal brain control of sub-lesional spinal cord events remains. Several lines of evidence suggest that, after SCI, behavioral deficits are often more severe than would be predicted from measures of anatomical injury. If true, this suggests the potential to improve motor status in the setting of a fixed lesion, even when deficits are severe.