INVESTIGATION OF WHITE MATTER INTEGRITY IN BIPOLAR DISORDER

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 虽然有证据表明双相情感障碍患者的大脑白质中存在信号高信号，但据我们所知，还没有关于双相情感障碍中涉及情绪处理的白质连接区域的研究。在这项研究中，我们建议通过使用扩散张量成像来研究双相情感障碍患者和健康对照组在脑白质束水自扩散方面的可能组差异，以及在眼眶额叶和杏仁核的结构性组差异。据推测，与健康志愿者相比，患者钩状束的分数各向异性较低，眼眶额叶和杏仁核的结构改变较低。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. While there is evidence for signal hyperintensities in the brain white matter of individuals with bipolar disorder, to our knowledge there has been no investigation of the white matter connecting regions involved in emotional processing in bipolar disorder. In this study, we propose to investigate, through the use of diffusion tensor imaging possible group differences between patients with bipolar disorder and healthy controls in the water self-diffusion of brain white matter tracts, and structural group differences in the orbital frontal lobe and amygdala. It is hypothesized that compared to healthy volunteers, patients will have lower fractional anisotropy in the uncinate fasciculus, lower orbital frontal N-accetyl-aspartate, and structural alterations in the orbital frontal lobe and amygdala.