PREVENTION OF ORAL CANCER BY TEA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究是针对健康志愿者的。参与者将被分成两组：目前吸烟者和不吸烟者的对照组。在两组中，绿茶和红茶、咖啡因水和水(安慰剂)将被饮用4周，最初的3周磨合期和2周的“冲洗期”。在这些治疗期间，每周采集口腔细胞，每周采集尿样，每两周采集血液。最初将对参与者进行临床评估，然后每月进行。参与者将被要求每周访问一次诊所。这项研究将持续25周，包括治疗。 我们的目标是研究一类被称为环加合物的多不饱和脂肪酸氧化形成的DNA损伤在导致肝癌中的特定生物学作用。在美国，肝癌的发病率正在上升，有证据表明，肥胖和脂肪肝是潜在的危险因素。因此，我们的长期目标是产生信息，以便阐明肝癌中肥胖的可能机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is for healthy volunteers. Participants will be divided into two groups: current smokers and a control group of non-smokers. In both groups, green tea and black tea, caffeinated water and water (placebo) will be drunk for 4 weeks each treatment with an initial 3-week run-in and 2-week "washout" period. During these treatment periods, oral cells will be collected weekly, urine samples weekly, and blood will be collected bi-weekly. Clinical evaluation of participants will be performed initially, then monthly. Participants will be required to visit the clinic once each week. The study will last, including treatments, 25 weeks. Our goal is to investigate the specific biological roles of one class of DNA damage formed by oxidation of polyunsaturated fatty acids called cyclic adducts in causing liver cancer. Incidences of liver cancer are on the rise in the U.S., and evidence indicates that obesity and fatty livers are potential risk factors. Therefore, our long-term goal is to generate information in order to shed light on possible mechanisms of obesity in liver cancer.