ATN 025: HEPATITIS B VACCINATION IN YOUTHS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这是一项在150名HIV阴性、B型肝炎核心抗体、B型肝炎表面抗原和表面抗体阴性青年中进行的两种B型肝炎免疫方案的II期、随机、单盲试验。 随机化将受到限制，因此两组中任一性别的受试者百分比均不超过60%。 疫苗接种将在0和6个月时以两剂的形式进行，主要结局将是6个月剂量后1个月的血清反应性。 还将评估安全性和耐受性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a Phase II, randomized, single-blinded trial of two Hepatitis B immunization regimens in 150 HIV-negative, Hepatitis B core antibody, Hepatitis B surface antigen, and surface antibody negative youth. The randomization will be restricted, so that the percentage of either gender does not exceed 60% of the subjects on either of the two arms. Vaccinations will be given in a two-dose refimer at 0 and six months and the primary outcome will be seroresponsiveness one month after the six-month dose. Safety and tolerability will also be assessed.