Science in a Culture of Mentoring

描述(由申请人提供)：俄克拉荷马州医学研究基金会的十年科布雷：“导师文化中的科学(RR15577)在为我们州免疫学研究的增长提供基础方面具有变革性。Cobre为启动12个独立研究职业提供了指导和支持，基础设施已直接导致10个“非NCRR NIH研究所”计划或中心赠款。OMRF和俄克拉何马州现在可以合法地声称自己是美国的免疫学中心。现在，16名符合Cobre资格的调查人员提交了由指导和关键核心支持支持的项目。我们发现，指导和核心支持是我们成功的基础。人类单抗(HmAb)核心来源于科布雷支持的科学观察(自然，2008)，这允许在接种疫苗后快速生产hmAb。目前已经生产了300多个hmAb，还有许多项目在等待，这一核心准备提供独特的研究工具，使我们的Cobre研究人员能够取得重大进展。血清分析器和生物标志物核心扩展了OMRF在人类自身抗体检测、细胞因子/趋化因子测量、表位绘制和血清分析物开发方面的优势。它将提供对质量控制数据的集中生成的访问，以帮助在自身免疫、基因-环境相互作用和人类免疫反应方面的项目。免疫表型鉴定核心应用新的全血多参数测试，对B细胞、T细胞和其他细胞类型的详细亚群进行检测。该中心在许多基于免疫学的项目中为复杂的人类疾病问题提供集中的标准操作规程、测试试剂和实验设计。最后，临床核心为Cobre研究人员提供患者/对照识别、招募、表型表征和人类受试者培训，所有17个拟议的试点项目都要求使用这一核心。试点项目核心将通过为期一年的试点项目，确定、支持和指导符合科布雷条件的初级科学家。尽管前几年的工作卓有成效，但这个周期收到了17份申请。我们认为这些试点基金是我们在俄克拉荷马州免疫学重点未来计划的基础。管理核心将为16名符合科布雷标准的初级科学家提供指导团队和行政支持，实施和扩大多学科丰富计划，支持俄克拉荷马州调查人员之间的合作，评估和管理试点项目的有效性。我们相信，有了这些额外的资金，OMRF和俄克拉何马州可以拥有一个杰出的免疫学卓越中心。 公共卫生相关性(由申请者提供)：OMRF Cobre导致了俄克拉荷马州基于免疫学的临床相关研究的爆炸性扩张。通过外部招募和当地初级科学家的发展，这种资助机制在疫苗免疫学、自身免疫、阿尔茨海默氏症研究和其他复杂的人类疾病方面产生了令人兴奋的新发现。将这一富有成效的Cobre转变为核心中心将有助于启动更多新的调查职业，并促进来自其他各种国家机构的更多计划支持。

DESCRIPTION (provided by applicant): The Oklahoma Medical Research Foundation's ten-year COBRE, "Science in a Culture of Mentoring (RR15577) has been transformative in providing the foundation for growth in Immunology research in our state. This COBRE provided mentoring and support to launch 12 independent research careers and the infrastructure has led to 10 "non NCRR NIH institutes" program or center grants as a direct result of this funding. OMRF and Oklahoma can now legitimately claim to be a "Center" for Immunology in the United States. Now, 16 COBRE eligible investigators present projects to be supported by mentoring and critical Core support. We have found that Mentoring and Core support is fundamental to our success. The Human Monoclonal Antibody (hmAb) Core grows out of COBRE supported scientific observations (Nature 2008), which allow rapid production of hmAbs after vaccination. With over 300 hmAbs already produced and many projects waiting, this Core is poised to provide unique research tools that should allow our COBRE Investigators to make major advances. The Serum Analyte and Biomarker Core expands on OMRF's strengths in human autoantibody detection, cytokine/chemokine measurements, epitope mapping and serum analyte development. It will provide access to the centralized generation of quality controlled data to assist projects in autoimmunity, gene-environment interactions, and human immune responses. The Immunophenotyping Core applies new whole blood multiparameter testing of detailed subsets of B cells, T cells, and other cell types. This Core provides centralized SOPs, tested reagents and experimental designs for complex human disease questions in many immunology-based projects. Finally, the Clinical Core provides patient/control identification, recruitment, phenotype characterization and human subjects training to COBRE investigators, with all 17 proposed pilot projects requesting use of this Core. The Pilot Project Core will identify, support and mentor COBRE eligible junior scientists through one-year pilot projects. Extremely productive in prior years, 17 applications were received for this cycle. We view these pilot funds as fundamental to our plans for the future of our Immunology focus in Oklahoma. The Administrative Core will provide mentoring teams and administrative support to 16 COBRE eligible junior scientists, implement and expand multidisciplinary enrichment programs, support collaborations between Oklahoma investigators, evaluate and manage the effectiveness of pilot projects. We are confident that with these additional funds OMRF and Oklahoma can have an outstanding Center of Immunology Excellence. PUBLIC HEALTH RELEVANCE (provided by applicant): This OMRF COBRE has led to an explosive expansion in Immunology based, clinically relevant research in Oklahoma. Through outside recruits and development of local junior scientists, this funding mechanism has resulted in exciting new discoveries in vaccine immunology, autoimmunity, Alzheimer's' research and other complex human diseases. Transition of this productive COBRE to a Cores Center will help launch additional new investigative careers and facilitate additional Program support, from a variety of other national agencies.