Small Animal Imaging Shared Resource

小动物影像资源使用多种模式提供影像，包括深度分辨率或 平面荧光和生物发光成像、核磁共振、PET/CT和平面闪烁成像。一批 有经验的调查人员和有能力进行数据成像和辅助的技术人员 解释与资源相关。有用于处理动物的基础设施(例如，麻醉， 输液、监测生命体征)，并可促进和承担实施 新的成像方案和方法评价。资源是由放射化学支持的 实验室和分子合成实验室，并具有数据分析和归档的计算机能力。 小动物影像资源一直在促进和加强细胞和分子成像 在过去的10年里，它已经发展了实质性的基础设施。定期举办研讨会和座谈会 激发了来自不同背景的科学家和医生(工程师、 化学家、分子生物学家和肿瘤学家)将成像应用于肿瘤学中的问题，这一直是 通过授予几个人的赠款而得到认可。部分由U24 SAIRP(Pis Ralph)支持的资源 梅森和迪恩·雪莉)于2007年4月开始。该资源作为新技术的催化剂 协调新基础设施的协作和重点，例如，赢得NIH共享仪器拨款 用于2008年的卡尺(Xenogen)光谱，以及在小动物MRI和PET/CT方面的国际投资。 影像(放射学)和组织学(病理学)是大多数临床查房和诊断的基石。 成像技术越来越多地向下渗透到小动物研究，这与opfimated的可用性不谋而合。 成像仪器。人们认识到，分子生物学和药物设计的进步必须 转到活体评估。成像允许动物(肿瘤)作为自己的对照，实质上 提高研究效率。在许多情况下，动物模型(例如，转基因和基因敲除) 非常舒适和/或供不应求。许多试剂，例如新的治疗抗体都是可用的 只有少量的数量。需要的动物更少，节省了成本，满足了生物医学的伦理目标 研究。因此，最大限度地提高从个别受试者获得的信息和数据质量应 提高研究效率，将磺胺类药物推向临床。

The Small Animal Imaging Resource provides imaging using multiple modalifies including depth resolved or planar fluorescence and bioluminescent imaging, MRI, PET/CT, and planar scintigraphy. A number of experienced investigators and technical staff capable of undertaking imaging and assisfing in data interpretation are associated with the Resource. There is infrastructure for animal handling (e.g., anesthesia, infusion, monitoring vital signs) and can facilitate and undertake developmental studies for implementafion of new imaging protocols and evaluafion of methods. The Resource is supported by a radiochemistry laboratory and molecular synthesis laboratory and has computer capabilities for data analysis and archiving. The Small Animal Imaging Resource has been promofing and enhancing cellular and molecular imaging for the last 10 years and has developed substanfial infrastructure. Regular seminars and symposia have stimulated increasing interest among scienfists and physicians from diverse backgrounds (engineers, chemists, molecular biologists, and oncologists) to apply imaging to questions in oncology and this has been recognized by grants to several individuals. The Resource supported in part by a U24 SAIRP (Pis Ralph Mason and Dean Sherry) commenced in April 2007. The Resource serves as a catalyst for new collaborations and focus for coordinating new infrastructure, e.g., winning NIH Shared instrumentation grants for a Caliper (Xenogen) Spectrum in 2008 and Insfitutional investment in small animal MRI and PET/CT. Imaging (radiology) and histology (pathology) are the cornerstones of most clinical rounds and diagnoses. Increasingly, imaging is filtering down to small animal research, coinciding with the availability of opfimized imaging instrumentafion. There is a realization that progress in molecular biology and drug design must move to assessment in vivo. Imaging allows animals (tumors) to serve as their own controls, substanfially improving research efficiency. In many cases, animal models (e.g., transgenic and knockout) are exceedingly cosfiy and/or in short supply. Many reagents, e.g., novel therapeufic anfibodies are available only in small quantifies. Fewer animals are needed, saving on cost and meefing ethical goals for biomedical research. Thus, maximizing the information and quality of data obtained from individual subjects should enhance research efficiency and ulfimate translafion to the clinic.