DEVELOPMENTAL RESEARCH PROGRAM

发展研究计划(DRP)将为有价值的翻译项目提供种子资金 它们有可能显著提高我们预防、检测、诊断、分期或治疗的能力 多发性骨髓瘤。项目提案将在严格的、同行评审的两级程序中选出， 从一年一次的申请请求开始，该申请将传达给所有三家公司的调查人员 参与机构。在第一轮中，提案将被限制在四页以内，并被要求承担 NIH R01申请的格式，包括具体的目的、背景和意义，初步 研究内容、研究设计和研究方法。这些建议将由DRP主任和联合- 署长确定那些符合预先指定的资格标准的人，他们将被邀请提交一份 完整的十页申请书，使用相同的格式，包括预算和理由。在此期间 第二，提案将由DRP审查委员会审查，该委员会将包括领导人和/或 每个孢子项目的联合负责人、孢子核心的董事和/或联席董事，以及至少 四名外部科学咨询委员会成员和四名内部科学咨询成员 冲浪板。每年将选择最多四个项目进行资助，资助期限为一年，期间 进度报告将每六个月监测一次。延长支持可能会再持续一年， 但这将要求该项目成功地与明年的提案池竞争。通过这件事 机制，DRP的具体目标是：1.支持新的、高度翻译的研究项目 最大限度地利用孢子提供的新的研究机会；2.建立和 在孢子内的科学家之间或孢子外的科学家之间培养新的合作 机制；以及3.为孢子提供科学的灵活性，使其能够促进有前途的DRP 将项目设置为完全项目状态。在提交本申请之前，标准操作程序 上面概述的内容经过了成功的测试，并导致选择了几个有希望的建议作为 将考虑提供支助的项目类型的例子。值得注意的是，这些来自不同的 对具有重要翻译含义的各种方法感兴趣的一组投资人，以及 支持民进党未来的力量。

The Developmental Research Program (DRP) will provide seed funding to meritorious translational projects that have the potential for significantly advancing our ability to prevent, detect, diagnose, stage, or treat multiple myeloma. Project proposals will be selected in a rigorous, peer-reviewed, two-tiered process, starting with a once-yeariy request for applications that will be communicated to investigators at all three participafing institutions. In this first round, proposals will be limited to four pages, and required to assume the format of an NIH R01 applicafion, incorporafing specific aims, background and significance, preliminary studies, and research design and methods. These proposals will be reviewed by the DRP Director and Co- Director to identify those that meet the pre-specified eligibility criteria, and these will be invited to submit a full, ten-page applicafion, using the same format with the inclusion of a budget and justification. During this second fier, proposals will be reviewed by the DRP Review Committee, which will include Leaders and/or Co-Leaders of each of the SPORE Projects, Directors and/or Co-Directors of SPORE Cores, and at least four members of the External Scientific Advisory Board, and four members of the Internal Scientific Advisory Board. Up to four projects each year will be selected for funding and supported for one year, during which progress reports will be monitored every six months. Renewal of support may be possible for a second year, but will require the project to successfully compete with the next year's pool of proposals. Through this mechanism, the specific aims of the DRP are: 1. To support novel, highly translational research projects that take maximum advantage of the new research opportunities afforded by the SPORE; 2. To build and foster new collaborafions among scientists within SPOREs, or with scienfists outside the SPORE mechanism; and 3. To provide.scientific flexibility to the SPORE that will allow promofion of promising DRP projects to full Project status. Prior to the submission of this applicafion, the standard operating procedure outlined above was successfully tested, and led to the selection of several promising proposals to serve as examples of the types of projects that would be considered for support. Notably, these come from a diverse group of invesfigators interested in a variety of approaches with important translational implicafions, and support the future strength of the DRP.