Molecular mechanisms of neuronal survival

神经细胞的存活既依赖于生长促进因子，也依赖于神经传递释放的因子，这些因子可以通过超越细胞死亡途径促进神经退行性疾病的恢复。在神经系统中负责激活死亡途径的分子被称为p75。该项目将研究p75如何导致细胞死亡，突触信号如何阻止p75死亡通路的激活，以及阻断p75功能是否可以限制神经退行性变。

Nerve cell survival is dependent on both growth-promoting factors and factors released by neurotransmission, which can promote recovery in neurodegenerative conditions by overriding cell death pathways. The molecule responsible for activating death pathways in the nervous system is called p75. This project will investigate how p75 results in cell death, how synaptic signals can prevent the activation of the p75 death pathway and whether blocking p75 function can limit neurodegeneration.