NEBRASKA CENTER FOR VIROLOGY: AIDS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 爱滋病相关研究。内布拉斯加州病毒学中心(NCV；P20RR015635)成立于2000年，是一个多机构、跨学科的中心，将内布拉斯加州主要生物医学研究机构的病毒学专业知识和资源联系在一起：内布拉斯加州大学林肯分校、内布拉斯加州大学医学中心和克雷顿大学。NCV的研究人员研究人类、动物和植物病毒；他们的集体专业知识代表了一个国家的力量，并提供了一个在模型系统上进行合作的绝佳机会，这些模型系统有望导致新的方法来理解和治疗威胁人类健康和经济福祉的疾病。经过九年的Cobre计划支持，NCV正在发展全球研究和培训存在，并建立一个跨学科研究计划，解决关于传染病病原体及其宿主相互作用的基本问题，并创造一个环境，培养具有广泛病毒学知识的新一代创新研究人员。Cobre的支持使中心能够在每个参与的校园中建立大量集中的病毒学专业知识和资源；然而，要成为一个独立的中心，NCV必须加强其跨学科和跨校园的合作，并为其核心设施实施可持续发展计划。此外，几名有前途的初级教员正在进行非常有价值的研究，他们继续需要NCV的支持和指导才能获得独立。通过第三阶段Cobre资金建立的额外能力将使NCV能够实现其战略计划和长期愿景：成为国际公认的卓越研究中心，拥有为IDEA、地区和国际科学界服务的杰出核心设施。这一愿景将通过完成三个具体目标来实现：1)通过继续为初级教师提供有效的指导计划，赞助试点项目计划，并继续支持四个基本核心设施(行政、流式细胞术、显微镜和蛋白质组学)，提高NCV教职员工的研究生产率和外部资金潜力；2)通过新的合作伙伴关系和计划，加强NCV对翻译研究和病毒学研究培训和教育的关注，与全球的研究人员、临床医生和学生分享病毒免疫学和分子病毒学专业知识和科学资源；3)从Cobre第三阶段资金中脱颖而出，通过增加个人研究人员和合作赠款的生产率，使NCV的外部研究资金组合多样化，成为一个自我维持的病毒学卓越研究中心。 公共卫生相关性(由申请者提供)：第三阶段Cobre资助将理想地使内布拉斯加州病毒学中心能够提供所需的基础设施支持，以增加对不同病毒剂建立持续感染、与宿主相互作用、从一个宿主传播到另一个宿主并导致疾病的分子机制的了解-最终目标是促进治疗和预防此类感染的新战略。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. AIDS related research at NCV. Established during 2000, the Nebraska Center for Virology (NCV; P20RR015635) is a multi-institutional, interdisciplinary center linking the virology expertise and resources at Nebraska's major biomedical research institutions: the University of Nebraska-Lincoln, the University of Nebraska Medical Center, and Creighton University. NCV investigators study human, animal, and plant viruses; their collective expertise presents a national strength and an exceptional opportunity to collaborate on model systems expected to lead to new approaches to understand and treat diseases threatening human health and economic well-being. Following nine years of COBRE program support, the NCV is developing a global research and training presence, and establishing an interdisciplinary research program addressing fundamental questions about infectious agents and their host interactions and creating an environment that is producing a new generation of innovative researchers with a broad knowledge of virology. COBRE support has allowed the Center to establish a critical mass of focused virology expertise and resources on each participating campus; however, to become an independent center, the NCV must bolster its interdisciplinary and cross-campus collaborations and implement a sustainability plan for its core facilities. In addition, several promising junior faculty conducting highly meritorious research continue to need NCV support and mentoring to gain independence. Additional capacity built through Phase III COBRE funding will enable the NCV to realize its strategic plan and achieve its long-term vision: to become an internationally recognized center of research excellence, with outstanding core facilities that serve IDeA, regional, and international scientific communities. This vision will be realized by completing three specific aims: 1) increase the research productivity and external funding potential of NCV faculty by continuing an effective mentoring program for junior faculty, sponsoring a pilot project program, and continuing support for four essential core facilities (administrative, flow cytometry, microscopy, and proteomics); 2) strengthen the NCV's focus on translational research and virology research training and education through new partnerships and programs to share viral immunology and molecular virology expertise and scientific resources with researchers, clinicians, and students globally; and 3) emerge from COBRE Phase III funding as a self-sustaining center of research excellence in virology by diversifying the NCV's external research funding portfolio through increased individual-investigator and collaborative grant productivity. PUBLIC HEALTH RELEVANCE (provided by applicant): Phase III COBRE funding will ideally position the Nebraska Center for Virology to provide the infrastructure support needed to increase understanding of the molecular mechanisms by which different viral agents establish persistent infection, interact with the host, are transmitted from one host to another, and cause disease - with the ultimate goal of contributing to new strategies to treat and prevent such infections.